Practical and efficient acylation and tosylation of sterically hindered alcohols catalyzed with 1-methylimidazole

Qin Pei Wu*, Hua Liu, Hai Xia Liu, Xi Chen, Hao Wang, Qing Shan Zhang, Yun Zheng Li

*此作品的通讯作者

科研成果: 期刊稿件文章同行评审

6 引用 (Scopus)

摘要

Acylation of sterically hindered alcohols is frequently encountered in synthetic chemistry. An efficient and mild procedure for tosylation and esterification of sterically hindered hydroxyl groups with p-TsCl, Ac2O and Bz2O in the presence of 1-methylimidazole is described. It was observed that auxiliary base, triethylamine, accelerates the acylation reaction.

源语言英语
页(从-至)55-59
页数5
期刊Chemical Research in Chinese Universities
26
1
出版状态已出版 - 2010

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