Potent, easily synthesized huperzine A-tacrine hybrid acetylcholinesterase inhibitors

Paul R. Carlier; Da Ming Du; Yifan Han; Jing Liu; Yuan Ping Pang

doi:10.1016/S0960-894X(99)00396-0

Potent, easily synthesized huperzine A-tacrine hybrid acetylcholinesterase inhibitors

Paul R. Carlier^*, Da Ming Du, Yifan Han, Jing Liu, Yuan Ping Pang

^*此作品的通讯作者

科研成果: 期刊稿件 › 文章 › 同行评审

88 引用（Scopus）

摘要

Hybrid acetylcholinesterase inhibitors composed of a key fragment of huperzine A and an intact tacrine unit were prepared. The syntheses are quite direct, proceeding in a maximum of 4 linear steps from commercially available starting materials. The optimum hybrid inhibitor (±)-9g is 13-fold more potent than (-)-huperzine A, and 25-fold more potent than tacrine.

源语言	英语
页（从-至）	2335-2338
页数	4
期刊	Bioorganic and Medicinal Chemistry Letters
卷	9
期	16
DOI	https://doi.org/10.1016/S0960-894X(99)00396-0
出版状态	已出版 - 16 8月 1999
已对外发布	是

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AU - Han, Yifan

AU - Liu, Jing

AU - Pang, Yuan Ping

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AB - Hybrid acetylcholinesterase inhibitors composed of a key fragment of huperzine A and an intact tacrine unit were prepared. The syntheses are quite direct, proceeding in a maximum of 4 linear steps from commercially available starting materials. The optimum hybrid inhibitor (±)-9g is 13-fold more potent than (-)-huperzine A, and 25-fold more potent than tacrine.

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Potent, easily synthesized huperzine A-tacrine hybrid acetylcholinesterase inhibitors

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