Polyethylenimine-interlayered silver-shell magnetic-core microspheres as multifunctional SERS substrates

Chongwen Wang, Jiawen Xu, Junfeng Wang, Zhen Rong, Ping Li, Rui Xiao*, Shengqi Wang

*此作品的通讯作者

科研成果: 期刊稿件文章同行评审

64 引用 (Scopus)

摘要

The fabrication of an ideal noble metal modified magnetic microsphere as a high performance SERS substrate that possesses good dispersibility, strong magnetic responsiveness, and high sensitivity is still a challenge. Herein, we report a novel route for fabricating Ag-coated magnetic core-shell microspheres (Fe3O4@PEI@Ag) with most of the desired advantages by using polyethyleneimine (PEI) as an interlayer. The size and coverage level of the Ag-NPs shell on Fe3O4@PEI@Ag microspheres were easily controlled by varying the amount of AgNO3. Meanwhile, the magnetic core endowed the Fe3O4@PEI@Ag microspheres with superior magnetic nature, which enabled convenient separation and further enhanced Raman signals due to enrichment of targeted analytes and abundant interparticle hotspots created by magnetism-induced aggregation. Considering these features, Fe3O4@PEI@Ag is expected to be a versatile SERS substrate, which was verified by the detection of adsorbed PATP molecules and human IgG with a detection limit as low as 10-11 M and 10-14 g mL-1, respectively. Therefore, the novel Fe3O4@PEI@Ag microsphere has an enormous potential for practical SERS detection applications, especially in the field of quantitative detection of target proteins.

源语言英语
页(从-至)8684-8693
页数10
期刊Journal of Materials Chemistry C
3
33
DOI
出版状态已出版 - 21 7月 2015
已对外发布

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