TY - JOUR
T1 - Polyethylenimine-interlayered silver-shell magnetic-core microspheres as multifunctional SERS substrates
AU - Wang, Chongwen
AU - Xu, Jiawen
AU - Wang, Junfeng
AU - Rong, Zhen
AU - Li, Ping
AU - Xiao, Rui
AU - Wang, Shengqi
N1 - Publisher Copyright:
© The Royal Society of Chemistry 2015.
PY - 2015/7/21
Y1 - 2015/7/21
N2 - The fabrication of an ideal noble metal modified magnetic microsphere as a high performance SERS substrate that possesses good dispersibility, strong magnetic responsiveness, and high sensitivity is still a challenge. Herein, we report a novel route for fabricating Ag-coated magnetic core-shell microspheres (Fe3O4@PEI@Ag) with most of the desired advantages by using polyethyleneimine (PEI) as an interlayer. The size and coverage level of the Ag-NPs shell on Fe3O4@PEI@Ag microspheres were easily controlled by varying the amount of AgNO3. Meanwhile, the magnetic core endowed the Fe3O4@PEI@Ag microspheres with superior magnetic nature, which enabled convenient separation and further enhanced Raman signals due to enrichment of targeted analytes and abundant interparticle hotspots created by magnetism-induced aggregation. Considering these features, Fe3O4@PEI@Ag is expected to be a versatile SERS substrate, which was verified by the detection of adsorbed PATP molecules and human IgG with a detection limit as low as 10-11 M and 10-14 g mL-1, respectively. Therefore, the novel Fe3O4@PEI@Ag microsphere has an enormous potential for practical SERS detection applications, especially in the field of quantitative detection of target proteins.
AB - The fabrication of an ideal noble metal modified magnetic microsphere as a high performance SERS substrate that possesses good dispersibility, strong magnetic responsiveness, and high sensitivity is still a challenge. Herein, we report a novel route for fabricating Ag-coated magnetic core-shell microspheres (Fe3O4@PEI@Ag) with most of the desired advantages by using polyethyleneimine (PEI) as an interlayer. The size and coverage level of the Ag-NPs shell on Fe3O4@PEI@Ag microspheres were easily controlled by varying the amount of AgNO3. Meanwhile, the magnetic core endowed the Fe3O4@PEI@Ag microspheres with superior magnetic nature, which enabled convenient separation and further enhanced Raman signals due to enrichment of targeted analytes and abundant interparticle hotspots created by magnetism-induced aggregation. Considering these features, Fe3O4@PEI@Ag is expected to be a versatile SERS substrate, which was verified by the detection of adsorbed PATP molecules and human IgG with a detection limit as low as 10-11 M and 10-14 g mL-1, respectively. Therefore, the novel Fe3O4@PEI@Ag microsphere has an enormous potential for practical SERS detection applications, especially in the field of quantitative detection of target proteins.
UR - http://www.scopus.com/inward/record.url?scp=84939149653&partnerID=8YFLogxK
U2 - 10.1039/c5tc01839k
DO - 10.1039/c5tc01839k
M3 - Article
AN - SCOPUS:84939149653
SN - 2050-7526
VL - 3
SP - 8684
EP - 8693
JO - Journal of Materials Chemistry C
JF - Journal of Materials Chemistry C
IS - 33
ER -