TY - JOUR
T1 - One-pot three components synthesis of β-amido ketones
AU - Yang, Deli
AU - Li, Jiarong
AU - Sun, Kening
AU - Lu, Hongyan
AU - Liu, Mingxing
AU - Shi, Daxin
PY - 2013/11
Y1 - 2013/11
N2 - A series of β-amido-ketones were synthesized by one-pot three components condensation of various aldehydes, ketones and nitriles in the presence of TiCl4 with the assistance of acyl chloride at room temperature. The effects of amount of catalyst, reaction temperature and reaction time on the products yields were investigated. This methodology offers several advantages, such as mild reaction condition, operational simplicity, suitable for wide range of substrates, and excellent yields.
AB - A series of β-amido-ketones were synthesized by one-pot three components condensation of various aldehydes, ketones and nitriles in the presence of TiCl4 with the assistance of acyl chloride at room temperature. The effects of amount of catalyst, reaction temperature and reaction time on the products yields were investigated. This methodology offers several advantages, such as mild reaction condition, operational simplicity, suitable for wide range of substrates, and excellent yields.
KW - Multi-component synthesis
KW - Titanium tetrachloride
KW - β-amido ketones
UR - http://www.scopus.com/inward/record.url?scp=84891360183&partnerID=8YFLogxK
U2 - 10.6023/cjoc201306007
DO - 10.6023/cjoc201306007
M3 - Article
AN - SCOPUS:84891360183
SN - 0253-2786
VL - 33
SP - 2341
EP - 2348
JO - Chinese Journal of Organic Chemistry
JF - Chinese Journal of Organic Chemistry
IS - 11
ER -