One-pot NHC-assisted access to 2,3-dihydropyrimido[4,5-d]pyrimidin-4(1H)- ones

Mingxing Liu; Jiarong Li; Shu Chen; Danfei Huang; Hongxin Chai; Qi Zhang; Daxin Shi

doi:10.1039/c4ra05346j

One-pot NHC-assisted access to 2,3-dihydropyrimido[4,5-d]pyrimidin-4(1H)- ones

Mingxing Liu, Jiarong Li, Shu Chen, Danfei Huang, Hongxin Chai, Qi Zhang, Daxin Shi^*

^*此作品的通讯作者

化学与化工学院

Beijing Institute of Technology

科研成果: 期刊稿件 › 文章 › 同行评审

12 引用（Scopus）

摘要

An efficient N-heterocyclic carbene-assisted one-pot reaction for the synthesis of 2,3-dihydropyrimido[4,5-d]pyrimidin-4(1H)-ones from 2-(ethoxymethylene)malononitrile, guanidines (or amidines) and ketones (or aldehydes) has been developed. This highly efficient method includes a series of conversions such as Michael addition, cyclisation, isomerization, aromatization, then nucleophilic attack and Dimroth rearrangement. And it avoids complicated reagents and multiple steps.

源语言	英语
页（从-至）	35629-35634
页数	6
期刊	RSC Advances
卷	4
期	67
DOI	https://doi.org/10.1039/c4ra05346j
出版状态	已出版 - 2014

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abstract = "An efficient N-heterocyclic carbene-assisted one-pot reaction for the synthesis of 2,3-dihydropyrimido[4,5-d]pyrimidin-4(1H)-ones from 2-(ethoxymethylene)malononitrile, guanidines (or amidines) and ketones (or aldehydes) has been developed. This highly efficient method includes a series of conversions such as Michael addition, cyclisation, isomerization, aromatization, then nucleophilic attack and Dimroth rearrangement. And it avoids complicated reagents and multiple steps.",

author = "Mingxing Liu and Jiarong Li and Shu Chen and Danfei Huang and Hongxin Chai and Qi Zhang and Daxin Shi",

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T1 - One-pot NHC-assisted access to 2,3-dihydropyrimido[4,5-d]pyrimidin-4(1H)- ones

AU - Liu, Mingxing

AU - Li, Jiarong

AU - Chen, Shu

AU - Huang, Danfei

AU - Chai, Hongxin

AU - Zhang, Qi

AU - Shi, Daxin

PY - 2014

Y1 - 2014

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AB - An efficient N-heterocyclic carbene-assisted one-pot reaction for the synthesis of 2,3-dihydropyrimido[4,5-d]pyrimidin-4(1H)-ones from 2-(ethoxymethylene)malononitrile, guanidines (or amidines) and ketones (or aldehydes) has been developed. This highly efficient method includes a series of conversions such as Michael addition, cyclisation, isomerization, aromatization, then nucleophilic attack and Dimroth rearrangement. And it avoids complicated reagents and multiple steps.

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EP - 35634

JO - RSC Advances

JF - RSC Advances

IS - 67

ER -

One-pot NHC-assisted access to 2,3-dihydropyrimido[4,5-d]pyrimidin-4(1H)- ones

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