摘要
A new method was studied to synthesize 4-[4-(3-pyridinyl)-1H-imidazol-1-yl]-1-butanamine. 4(5)-(3-pyridyl)imidazole sodium salt was obtained from 3-(α-aminoacetyl)pyridine hydrochloride by formylation, cyclization and deprotonation. 4-[4-(3-pyridinyl)-1H-imidazol-1-yl]-1-butanamine was then synthesized via condensation of 4(5)-(3-pyridyl)imidazole sodium salt with N-(4-bromobutyl)phthalimide followed by hydrazinolysis. The gross yield is 54%. The new synthetic method is practical and efficient for its mild reaction conditions and the features of high yield and high purity.
| 源语言 | 英语 |
|---|---|
| 页（从-至） | 33-36 |
| 页数 | 4 |
| 期刊 | Beijing Ligong Daxue Xuebao/Transaction of Beijing Institute of Technology |
| 卷 | 27 |
| 期 | SUPPL. 2 |
| 出版状态 | 已出版 - 12月 2007 |