Near Infrared Light Sensitive Ultraviolet-Blue Nanophotoswitch for Imaging-Guided "off-On" Therapy

Jing Zuo, Langping Tu, Qiqing Li, Yansong Feng, Ivo Que, Youlin Zhang, Xiaomin Liu, Bin Xue, Luis J. Cruz, Yulei Chang*, Hong Zhang, Xianggui Kong

*此作品的通讯作者

科研成果: 期刊稿件文章同行评审

128 引用 (Scopus)

摘要

Photoswitchable materials are important in broad applications. Recently appeared inorganic photoswitchable upconversion nanoparticles (PUCNPs) become a competitive candidate to surmount the widespread issue of the organic counterparts - photobleaching. However, current PUCNPs follow solely Yb3+/Nd3+ cosensitizing mode, which results in complex multilayer doping patterns and imperfectness of switching in UV-blue region. In this work, we have adopted a new strategy to construct Nd3+ free PUCNPs - NaErF4@NaYF4@NaYbF4:0.5%Tm@NaYF4. These PUCNPs demonstrate the superior property of photoswitching. A prominent UV-blue emission from Tm3+ is turned on upon 980 nm excitation, which can be completely turned off by 800 nm light. The quasi-monochromatic red upconversion emission upon 800 nm excitation - a distinct feature of undoping NaErF4 upconversion system - endows the PUCNPs with promising image-guided photoinduced "off-on" therapy in biomedicine. As a proof-of-concept we have demonstrated the imaging-guided photodynamic therapy (PDT) of cancer, where 800 nm excitation turns off the UV-blue emission and leaves the emission at 660 nm for imaging. Once the tumor site is targeted, excitation switching to 980 nm results in UV-blue emission and the red emission. The former is used to induce PDT, whereas the latter is to monitor the therapeutic process. Our study implies that this upconversion photoswitching material is suitable for real-time imaging and image-guided therapy under temporal and spatial control.

源语言英语
页(从-至)3217-3225
页数9
期刊ACS Nano
12
4
DOI
出版状态已出版 - 24 4月 2018
已对外发布

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Zuo, J., Tu, L., Li, Q., Feng, Y., Que, I., Zhang, Y., Liu, X., Xue, B., Cruz, L. J., Chang, Y., Zhang, H., & Kong, X. (2018). Near Infrared Light Sensitive Ultraviolet-Blue Nanophotoswitch for Imaging-Guided "off-On" Therapy. ACS Nano, 12(4), 3217-3225. https://doi.org/10.1021/acsnano.7b07393