N-Thiocyanatosaccharin: A "sweet" Electrophilic Thiocyanation Reagent and the Synthetic Applications

Di Wu, Jiashen Qiu, Pran Gopal Karmaker, Hongquan Yin*, Fu Xue Chen

*此作品的通讯作者

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94 引用 (Scopus)

摘要

N-Thiocyanatosaccharin (R1) was readily prepared from the sweet additive Saccharin in two steps with a 71% overall yield. By applying this new reagent to diverse nucleophiles such as benzothiophenes, indoles, oxindoles, aromatic amines, phenols, β-keto carbonyl compounds, and aromatic ketones, a novel electrophilic thiocyanation reaction was achieved with high yields (up to 99%). The potential recycling of Saccharin, the wide scope of substrates, and the mild reaction conditions made this protocol much more practical.

源语言英语
页(从-至)1576-1583
页数8
期刊Journal of Organic Chemistry
83
3
DOI
出版状态已出版 - 2 2月 2018

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