Multisite simultaneous neural recording of motor pathway in free-moving rats

Yiran Lang, Rongyu Tang, Yafei Liu, Pengcheng Xi, Honghao Liu, Zhenzhen Quan, Da Song, Xiaodong Lv, Qiang Huang, Jiping He*

*此作品的通讯作者

科研成果: 期刊稿件文章同行评审

4 引用 (Scopus)

摘要

Neural interfaces typically focus on one or two sites in the motoneuron system simulta-neously due to the limitation of the recording technique, which restricts the scope of observation and discovery of this system. Herein, we built a system with various electrodes capable of recording a large spectrum of electrophysiological signals from the cortex, spinal cord, peripheral nerves, and muscles of freely moving animals. The system integrates adjustable microarrays, floating mi-croarrays, and microwires to a commercial connector and cuff electrode on a wireless transmitter. To illustrate the versatility of the system, we investigated its performance for the behavior of rodents during tethered treadmill walking, untethered wheel running, and open field exploration. The results indicate that the system is stable and applicable for multiple behavior conditions and can provide data to support previously inaccessible research of neural injury, rehabilitation, brain-inspired computing, and fundamental neuroscience.

源语言英语
文章编号503
期刊Biosensors
11
12
DOI
出版状态已出版 - 12月 2021

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Lang, Y., Tang, R., Liu, Y., Xi, P., Liu, H., Quan, Z., Song, D., Lv, X., Huang, Q., & He, J. (2021). Multisite simultaneous neural recording of motor pathway in free-moving rats. Biosensors, 11(12), 文章 503. https://doi.org/10.3390/bios11120503