Multidrug resistance protein expression of adult T-cell leukemia/lymphoma

Takeshi Yasunami; Yan hua Wang; Kazue Tsuji; Minoko Takanashi; Yasuaki Yamada; Toshiko Motoji

doi:10.1016/j.leukres.2006.10.012

Multidrug resistance protein expression of adult T-cell leukemia/lymphoma

Takeshi Yasunami, Yan hua Wang, Kazue Tsuji, Minoko Takanashi, Yasuaki Yamada, Toshiko Motoji^*

^*此作品的通讯作者

科研成果: 期刊稿件 › 文章 › 同行评审

14 引用（Scopus）

摘要

In adult T-cell leukemia/lymphoma (ATL), it is difficult to achieve remission and the reason for the resistance to chemotherapeutic agents may be linked to the presence of multidrug resistance (MDR) proteins. Lung resistance-related protein (LRP), multidrug resistance-associated protein and P-glycoprotein are three MDR proteins which we examined in ATL cells using multiparametric flow cytometry and real-time RT-PCR. LRP was highly expressed and suppressing LRP function increased doxorubicin accumulation in nuclei. This indicates LRP may be contributing to drug resistance in ATL patients, and the suppression of LRP function could be a new strategy for ATL treatment.

源语言	英语
页（从-至）	465-470
页数	6
期刊	Leukemia Research
卷	31
期	4
DOI	https://doi.org/10.1016/j.leukres.2006.10.012
出版状态	已出版 - 4月 2007
已对外发布	是

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10.1016/j.leukres.2006.10.012

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title = "Multidrug resistance protein expression of adult T-cell leukemia/lymphoma",

abstract = "In adult T-cell leukemia/lymphoma (ATL), it is difficult to achieve remission and the reason for the resistance to chemotherapeutic agents may be linked to the presence of multidrug resistance (MDR) proteins. Lung resistance-related protein (LRP), multidrug resistance-associated protein and P-glycoprotein are three MDR proteins which we examined in ATL cells using multiparametric flow cytometry and real-time RT-PCR. LRP was highly expressed and suppressing LRP function increased doxorubicin accumulation in nuclei. This indicates LRP may be contributing to drug resistance in ATL patients, and the suppression of LRP function could be a new strategy for ATL treatment.",

keywords = "Adult T-cell leukemia/lymphoma, Lung resistance-related protein (LRP), Multidrug resistance protein (MDR), Multidrug resistance-associated protein (MRP), P-glycoprotein (P-gp)",

author = "Takeshi Yasunami and Wang, {Yan hua} and Kazue Tsuji and Minoko Takanashi and Yasuaki Yamada and Toshiko Motoji",

year = "2007",

month = apr,

doi = "10.1016/j.leukres.2006.10.012",

language = "English",

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journal = "Leukemia Research",

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TY - JOUR

T1 - Multidrug resistance protein expression of adult T-cell leukemia/lymphoma

AU - Yasunami, Takeshi

AU - Wang, Yan hua

AU - Tsuji, Kazue

AU - Takanashi, Minoko

AU - Yamada, Yasuaki

AU - Motoji, Toshiko

PY - 2007/4

Y1 - 2007/4

N2 - In adult T-cell leukemia/lymphoma (ATL), it is difficult to achieve remission and the reason for the resistance to chemotherapeutic agents may be linked to the presence of multidrug resistance (MDR) proteins. Lung resistance-related protein (LRP), multidrug resistance-associated protein and P-glycoprotein are three MDR proteins which we examined in ATL cells using multiparametric flow cytometry and real-time RT-PCR. LRP was highly expressed and suppressing LRP function increased doxorubicin accumulation in nuclei. This indicates LRP may be contributing to drug resistance in ATL patients, and the suppression of LRP function could be a new strategy for ATL treatment.

AB - In adult T-cell leukemia/lymphoma (ATL), it is difficult to achieve remission and the reason for the resistance to chemotherapeutic agents may be linked to the presence of multidrug resistance (MDR) proteins. Lung resistance-related protein (LRP), multidrug resistance-associated protein and P-glycoprotein are three MDR proteins which we examined in ATL cells using multiparametric flow cytometry and real-time RT-PCR. LRP was highly expressed and suppressing LRP function increased doxorubicin accumulation in nuclei. This indicates LRP may be contributing to drug resistance in ATL patients, and the suppression of LRP function could be a new strategy for ATL treatment.

KW - Adult T-cell leukemia/lymphoma

KW - Lung resistance-related protein (LRP)

KW - Multidrug resistance protein (MDR)

KW - Multidrug resistance-associated protein (MRP)

KW - P-glycoprotein (P-gp)

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U2 - 10.1016/j.leukres.2006.10.012

DO - 10.1016/j.leukres.2006.10.012

M3 - Article

C2 - 17134750

AN - SCOPUS:33846705561

SN - 0145-2126

VL - 31

SP - 465

EP - 470

JO - Leukemia Research

JF - Leukemia Research

IS - 4

ER -

Multidrug resistance protein expression of adult T-cell leukemia/lymphoma

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