TY - JOUR
T1 - Multi-aryl pyrroles
T2 - Exploring aggregation-induced emission for the biological/medical applications
AU - Qu, Jiamin
AU - Shi, Jianbing
AU - Tong, Bin
AU - Cai, Zhengxu
AU - Zhi, Junge
AU - Dong, Yuping
N1 - Publisher Copyright:
© 2025
PY - 2025/4
Y1 - 2025/4
N2 - Pyrrole is one of the most common five-membered heterocycles, and its units can be found in many natural products (such as chlorophyll and vitamin B12) and biologically active drugs (e.g., atorvastatin and calcimycin). Owing to their electron-rich properties and multiple modifiable sites, pyrrole derivatives have been widely developed and used in various fields, including medicine and optoelectronic materials. For more than 10 years, we have been working on the development of multi-aryl pyrroles (MAPs) considering the characteristics of aggregation-induced emission (AIE) for biological diagnostic applications. Herein, the structural design of MAPs and their corresponding AIE properties were briefly introduced. Then, MAPs that emit across the full spectrum from ultraviolet–visible to near-infrared II wavelengths were summarized for their application in analyzing and detecting biological substances, bioimaging, and phototherapy. Finally, we demonstrate the potential of MAPs in advancing biomedicine, clinical diagnosis, and cancer treatment.
AB - Pyrrole is one of the most common five-membered heterocycles, and its units can be found in many natural products (such as chlorophyll and vitamin B12) and biologically active drugs (e.g., atorvastatin and calcimycin). Owing to their electron-rich properties and multiple modifiable sites, pyrrole derivatives have been widely developed and used in various fields, including medicine and optoelectronic materials. For more than 10 years, we have been working on the development of multi-aryl pyrroles (MAPs) considering the characteristics of aggregation-induced emission (AIE) for biological diagnostic applications. Herein, the structural design of MAPs and their corresponding AIE properties were briefly introduced. Then, MAPs that emit across the full spectrum from ultraviolet–visible to near-infrared II wavelengths were summarized for their application in analyzing and detecting biological substances, bioimaging, and phototherapy. Finally, we demonstrate the potential of MAPs in advancing biomedicine, clinical diagnosis, and cancer treatment.
KW - Aggregation-induced emission
KW - Biological diagnostics
KW - Multi-aryl pyrroles
KW - Near-infrared region
UR - http://www.scopus.com/inward/record.url?scp=85214310867&partnerID=8YFLogxK
U2 - 10.1016/j.dyepig.2025.112633
DO - 10.1016/j.dyepig.2025.112633
M3 - Review article
AN - SCOPUS:85214310867
SN - 0143-7208
VL - 235
JO - Dyes and Pigments
JF - Dyes and Pigments
M1 - 112633
ER -