TY - JOUR
T1 - Mixed Metal Metal-Organic Frameworks Derived Carbon Supporting ZnFe2O4/C for High-Performance Magnetic Particle Imaging
AU - Jiang, Zhenqi
AU - Han, Xiao
AU - Du, Yang
AU - Li, Yanying
AU - Li, Yong
AU - Li, Juan
AU - Tian, Jie
AU - Wu, Aiguo
N1 - Publisher Copyright:
© 2021 American Chemical Society.
PY - 2021/4/14
Y1 - 2021/4/14
N2 - Recently, magnetic particle imaging (MPI) has shown diverse biomedical applications such as cell tracking, lung perfusion, image-guided hyperthermia, and so forth. However, the currently reported MPI agents cannot achieve the possible theoretical detection limit of MPI (20 nM). A previous theoretical study has shown that the MPI performance of superparamagnetic iron oxide nanoparticles (SPIONs) can be enhanced by carbon supporting and metal doping. In the current study, a series of mixed metal metal-organic framework-derived carbon supporting SPIONs were synthesized by pyrolysis. Among the synthesized SPIONs, the MPI signal intensity of ZnFe2O4/C@PDA was found to be 4.7 times higher than the commercial MPI contrast (Vivotrax) having the same Fe concentration. ZnFe2O4/C@PDA also showed the highest MPI intensity in tumor-bearing-mice among all tested samples. Furthermore, they were found highly biocompatible and showed linear cell quantification. This work can open new avenues for the design and development of novel and high-performance MPI agents.
AB - Recently, magnetic particle imaging (MPI) has shown diverse biomedical applications such as cell tracking, lung perfusion, image-guided hyperthermia, and so forth. However, the currently reported MPI agents cannot achieve the possible theoretical detection limit of MPI (20 nM). A previous theoretical study has shown that the MPI performance of superparamagnetic iron oxide nanoparticles (SPIONs) can be enhanced by carbon supporting and metal doping. In the current study, a series of mixed metal metal-organic framework-derived carbon supporting SPIONs were synthesized by pyrolysis. Among the synthesized SPIONs, the MPI signal intensity of ZnFe2O4/C@PDA was found to be 4.7 times higher than the commercial MPI contrast (Vivotrax) having the same Fe concentration. ZnFe2O4/C@PDA also showed the highest MPI intensity in tumor-bearing-mice among all tested samples. Furthermore, they were found highly biocompatible and showed linear cell quantification. This work can open new avenues for the design and development of novel and high-performance MPI agents.
KW - Esophageal Squamous Cell Cancer
KW - High-Temperature Pyrolysis
KW - Magnetic Particle Imaging
KW - Metal-Organic Frameworks
UR - http://www.scopus.com/inward/record.url?scp=85104275525&partnerID=8YFLogxK
U2 - 10.1021/acs.nanolett.0c04455
DO - 10.1021/acs.nanolett.0c04455
M3 - Article
C2 - 33797257
AN - SCOPUS:85104275525
SN - 1530-6984
VL - 21
SP - 2730
EP - 2737
JO - Nano Letters
JF - Nano Letters
IS - 7
ER -
