摘要
A Lewis acid-promoted electrophilic thiocyanation/cyclization of ortho-alkynylanilines for the synthesis of indole derivatives has been developed. The reaction utilizes Me3SiBr as the Lewis acid and N-thiocyanatosuccinimide as the thiocyanation reagent. A series of 2-aryl-3-thiocyanato indoles were prepared in moderate to high yields under mild conditions without metals and oxidants. It provides an efficient protocol for the construction of the indole skeleton and C-SCN and C-N bonds in one step as well.
源语言 | 英语 |
---|---|
页(从-至) | 4031-4035 |
页数 | 5 |
期刊 | Organic and Biomolecular Chemistry |
卷 | 22 |
期 | 20 |
DOI | |
出版状态 | 已出版 - 25 4月 2024 |