Me3SiBr-promoted cascade electrophilic thiocyanation/cyclization of ortho-alkynylanilines to synthesize indole derivatives

Qing Wang, Chukai Shao, Ruirui Hua, Hongquan Yin, Fu Xue Chen*

*此作品的通讯作者

科研成果: 期刊稿件文章同行评审

摘要

A Lewis acid-promoted electrophilic thiocyanation/cyclization of ortho-alkynylanilines for the synthesis of indole derivatives has been developed. The reaction utilizes Me3SiBr as the Lewis acid and N-thiocyanatosuccinimide as the thiocyanation reagent. A series of 2-aryl-3-thiocyanato indoles were prepared in moderate to high yields under mild conditions without metals and oxidants. It provides an efficient protocol for the construction of the indole skeleton and C-SCN and C-N bonds in one step as well.

源语言英语
页(从-至)4031-4035
页数5
期刊Organic and Biomolecular Chemistry
22
20
DOI
出版状态已出版 - 25 4月 2024

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