Mechanism study on improving chiral separation capacity of HPLC system choosing tertiary butyl alcohol as mobile phase and β-cyclodextrin stationary phase

Zhong Jie Zhao; Zhen He Chen; Wen Tao Zhao; Rui Jiang; Fu Ming Wang; Ai Qin Luo

Mechanism study on improving chiral separation capacity of HPLC system choosing tertiary butyl alcohol as mobile phase and β-cyclodextrin stationary phase

Zhong Jie Zhao, Zhen He Chen, Wen Tao Zhao, Rui Jiang, Fu Ming Wang, Ai Qin Luo^*

^*此作品的通讯作者

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摘要

This paper represents a new high-performance liquid chromatography (HPLC) system which consists of butyl-alcohol as mobile phase and β-cyclodextrin stationary phase. The model of molecular interactions among tertiary-butyl alcohol, normal-butyl-alcohol, 2-butyl-alcohol and cyclodextrin has been built and verified via computer simulation and spectro-photometric approach. By choosing tert-butyl-alcohol as the mobile phase, five types of enantiomers have been separated successfully. This result suggests that the improvement of chiral selectivity of HPLC system might be attributed to the competitive interaction between butyl-alcohol and cyclodextrin.

源语言	英语
页（从-至）	761-765
页数	5
期刊	Beijing Ligong Daxue Xuebao/Transaction of Beijing Institute of Technology
卷	32
期	7
出版状态	已出版 - 7月 2012

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@article{26f46d30d67c4e58b3f6a4e80c7dc30b,

title = "Mechanism study on improving chiral separation capacity of HPLC system choosing tertiary butyl alcohol as mobile phase and β-cyclodextrin stationary phase",

abstract = "This paper represents a new high-performance liquid chromatography (HPLC) system which consists of butyl-alcohol as mobile phase and β-cyclodextrin stationary phase. The model of molecular interactions among tertiary-butyl alcohol, normal-butyl-alcohol, 2-butyl-alcohol and cyclodextrin has been built and verified via computer simulation and spectro-photometric approach. By choosing tert-butyl-alcohol as the mobile phase, five types of enantiomers have been separated successfully. This result suggests that the improvement of chiral selectivity of HPLC system might be attributed to the competitive interaction between butyl-alcohol and cyclodextrin.",

keywords = "Butyl-alcohol, Fading spectro-photometric method, High-performance liquid chromatography(HPLC), Molecular simulation, β-cyclodextrin",

author = "Zhao, {Zhong Jie} and Chen, {Zhen He} and Zhao, {Wen Tao} and Rui Jiang and Wang, {Fu Ming} and Luo, {Ai Qin}",

year = "2012",

month = jul,

language = "English",

volume = "32",

pages = "761--765",

journal = "Beijing Ligong Daxue Xuebao/Transaction of Beijing Institute of Technology",

issn = "1001-0645",

publisher = "Beijing Institute of Technology",

number = "7",

}

Mechanism study on improving chiral separation capacity of HPLC system choosing tertiary butyl alcohol as mobile phase and β-cyclodextrin stationary phase. / Zhao, Zhong Jie; Chen, Zhen He; Zhao, Wen Tao 等.
在: Beijing Ligong Daxue Xuebao/Transaction of Beijing Institute of Technology, 卷 32, 号码 7, 07.2012, 页码 761-765.

科研成果: 期刊稿件 › 文章 › 同行评审

TY - JOUR

T1 - Mechanism study on improving chiral separation capacity of HPLC system choosing tertiary butyl alcohol as mobile phase and β-cyclodextrin stationary phase

AU - Zhao, Zhong Jie

AU - Chen, Zhen He

AU - Zhao, Wen Tao

AU - Jiang, Rui

AU - Wang, Fu Ming

AU - Luo, Ai Qin

PY - 2012/7

Y1 - 2012/7

N2 - This paper represents a new high-performance liquid chromatography (HPLC) system which consists of butyl-alcohol as mobile phase and β-cyclodextrin stationary phase. The model of molecular interactions among tertiary-butyl alcohol, normal-butyl-alcohol, 2-butyl-alcohol and cyclodextrin has been built and verified via computer simulation and spectro-photometric approach. By choosing tert-butyl-alcohol as the mobile phase, five types of enantiomers have been separated successfully. This result suggests that the improvement of chiral selectivity of HPLC system might be attributed to the competitive interaction between butyl-alcohol and cyclodextrin.

AB - This paper represents a new high-performance liquid chromatography (HPLC) system which consists of butyl-alcohol as mobile phase and β-cyclodextrin stationary phase. The model of molecular interactions among tertiary-butyl alcohol, normal-butyl-alcohol, 2-butyl-alcohol and cyclodextrin has been built and verified via computer simulation and spectro-photometric approach. By choosing tert-butyl-alcohol as the mobile phase, five types of enantiomers have been separated successfully. This result suggests that the improvement of chiral selectivity of HPLC system might be attributed to the competitive interaction between butyl-alcohol and cyclodextrin.

KW - Butyl-alcohol

KW - Fading spectro-photometric method

KW - High-performance liquid chromatography(HPLC)

KW - Molecular simulation

KW - β-cyclodextrin

UR - http://www.scopus.com/inward/record.url?scp=84867415347&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:84867415347

SN - 1001-0645

VL - 32

SP - 761

EP - 765

JO - Beijing Ligong Daxue Xuebao/Transaction of Beijing Institute of Technology

JF - Beijing Ligong Daxue Xuebao/Transaction of Beijing Institute of Technology

IS - 7

ER -

Mechanism study on improving chiral separation capacity of HPLC system choosing tertiary butyl alcohol as mobile phase and β-cyclodextrin stationary phase

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