Manipulating Host-Guest Charge Transfer of a Water-Soluble Double-Cavity Cyclophane for NIR-II Photothermal Therapy

Ran Li, Fei Yang, Liying Zhang, Mengzhen Li, Guo Wang*, Weizhi Wang, Yanqing Xu, Wei Wei*

*此作品的通讯作者

科研成果: 期刊稿件文章同行评审

18 引用 (Scopus)

摘要

Water-soluble small organic photothermal agents (PTAs) over NIR-II biowindow (1000–1350 nm) are highly desirable, but the rarity greatly limits their applications. Based on a water-soluble double-cavity cyclophane GBox-44+, we report a class of host–guest charge transfer (CT) complexes as structurally uniform PTAs for NIR-II photothermal therapy. As a result of its high electron-deficiency, GBox-44+ can bind different electron-rich planar guests with a 1 : 2 host/guest stoichiometry to readily tune the CT absorption band that extends to the NIR-II region. When using a diaminofluorene guest substituted with an oligoethylene glycol chain, the host–guest system realized both good biocompatibility and enhanced photothermal conversion at 1064 nm, and was then exploited as a high-efficiency NIR-II PTA for cancer cell and bacterial ablation. This work broadens the potential applications of host–guest cyclophane systems and provides a new access to bio-friendly NIR-II photoabsorbers with well-defined structures.

源语言英语
文章编号e202301267
期刊Angewandte Chemie - International Edition
62
17
DOI
出版状态已出版 - 17 4月 2023

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Li, R., Yang, F., Zhang, L., Li, M., Wang, G., Wang, W., Xu, Y., & Wei, W. (2023). Manipulating Host-Guest Charge Transfer of a Water-Soluble Double-Cavity Cyclophane for NIR-II Photothermal Therapy. Angewandte Chemie - International Edition, 62(17), 文章 e202301267. https://doi.org/10.1002/anie.202301267