Light intensity alters the effects of light-induced circadian disruption on glucose and lipid metabolism in mice

Xiaojing Fan, Defu Chen, Ying Wang, Yizhou Tan, Hongyou Zhao, Jing Zeng, Yunqi Li, Xianghuan Guo, Haixia Qiu*, Ying Gu*

*此作品的通讯作者

科研成果: 期刊稿件文章同行评审

16 引用 (Scopus)

摘要

Circadian disruption induced by rotating light cycles has been linked to metabolic disorders. However, how the interaction of light intensity and light cycle affects metabolism under different diets remains to be explored. Eighty mice were first randomly stratified into the low-fat diet (LFD, n = 40) or high-fat diet (HFD, n = 40) groups. Each group was further randomly subdivided into four groups (n = 8-12 per group) in terms of different light intensities [lower (LI, 78 lx) or higher intensity (HI, 169 lx)] and light cycles [12-h light:12-h dark cycle or circadian-disrupting (CD) light cycle consisting of repeated 6-h light phase advancement]. Body weight was measured weekly. At the end of the 16-wk experiment, mice were euthanized for serum and pathological analysis. Glucose and insulin tolerance tests were performed during the last 2 wk. The CD cycle increased body weight gain, adipocyte area, glucose intolerance, and insulin resistance of LFD as well as HFD mice under HI but not LI condition. Moreover, the serum and hepatic triglyceride levels increased with LFD-HI treatment, regardless of light cycle. In addition, the CD cycle improved lipid and glucose metabolism under HFD-LI condition. In summary, the detrimental effects of the CD cycle on metabolism were alleviated under LI condition, especially in HFD mice. These results indicate that modulating light intensity is a potential strategy to prevent the negative metabolic consequences associated with jet lag or shift work.

源语言英语
页(从-至)E1-E9
期刊American Journal of Physiology - Endocrinology and Metabolism
322
1
DOI
出版状态已出版 - 1月 2022

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Fan, X., Chen, D., Wang, Y., Tan, Y., Zhao, H., Zeng, J., Li, Y., Guo, X., Qiu, H., & Gu, Y. (2022). Light intensity alters the effects of light-induced circadian disruption on glucose and lipid metabolism in mice. American Journal of Physiology - Endocrinology and Metabolism, 322(1), E1-E9. https://doi.org/10.1152/AJPENDO.00025.2021