TY - GEN
T1 - Lattice Boltzmann study of micro branch array of crossflow filtration for fluid partitioning
AU - Cheng, Shiyu
AU - Xu, Yuanqing
AU - Tang, Xiaoying
AU - Yang, Rui
PY - 2013
Y1 - 2013
N2 - In the past decade, a flurry of new blood cells separation methods based microfluidic chip technology has emerged to address clinical diagnosis and biological research. The crossflow-based filtration separation method, because of its simple working principle and effectively overcoming the chip clogging problem, is gradually developing as an attractive solution for blood cells separation. In order to investigate and optimize the structure of a crossflow-based separator for blood cells, we studied how the tilt angle of the micro branch channel in the pillar array affects the fluid partitioning of low Reynolds number using Lattice Boltzmann (LBM) method. The reliability of using LBM to solve the flow of fluid of low Reynolds number is validated by the simulation of Poiseuille flow, and then a model of the branch channel, which mainly focuses on 4 different tilt angle (30°, 45°, 60°, 90°), is built to simulate. For far upstream and downstream in the main channel, and downstream in the side branch array channels, the fluid velocity profiles are assumed to adopt those of unidirectional Poiseuille flow with prescribed flow rates. The results show that the angle of inclination, with other conditions constant, will significantly influence the partition of fluid in the main channel and side branch array channels. Generally the larger the tilt angle is, the larger the rate flow in the branch array channel is, or vice versa.
AB - In the past decade, a flurry of new blood cells separation methods based microfluidic chip technology has emerged to address clinical diagnosis and biological research. The crossflow-based filtration separation method, because of its simple working principle and effectively overcoming the chip clogging problem, is gradually developing as an attractive solution for blood cells separation. In order to investigate and optimize the structure of a crossflow-based separator for blood cells, we studied how the tilt angle of the micro branch channel in the pillar array affects the fluid partitioning of low Reynolds number using Lattice Boltzmann (LBM) method. The reliability of using LBM to solve the flow of fluid of low Reynolds number is validated by the simulation of Poiseuille flow, and then a model of the branch channel, which mainly focuses on 4 different tilt angle (30°, 45°, 60°, 90°), is built to simulate. For far upstream and downstream in the main channel, and downstream in the side branch array channels, the fluid velocity profiles are assumed to adopt those of unidirectional Poiseuille flow with prescribed flow rates. The results show that the angle of inclination, with other conditions constant, will significantly influence the partition of fluid in the main channel and side branch array channels. Generally the larger the tilt angle is, the larger the rate flow in the branch array channel is, or vice versa.
KW - Lattice Boltzmann method
KW - branch array channels
KW - crossflow filtration
KW - fluid partitioning
KW - modeling
UR - http://www.scopus.com/inward/record.url?scp=84881516592&partnerID=8YFLogxK
U2 - 10.1109/ICCME.2013.6548318
DO - 10.1109/ICCME.2013.6548318
M3 - Conference contribution
AN - SCOPUS:84881516592
SN - 9781467329699
T3 - 2013 ICME International Conference on Complex Medical Engineering, CME 2013
SP - 586
EP - 589
BT - 2013 ICME International Conference on Complex Medical Engineering, CME 2013
T2 - 2013 7th ICME International Conference on Complex Medical Engineering, CME 2013
Y2 - 25 May 2013 through 28 May 2013
ER -