Isolation and structural identification of lignans from Dregea sinensis Hemsl

Shao Hua Jia; Fang Lü; Rong Ji Dai; Wei Wei Meng; Yan Chen; Yu Lin Deng

doi:10.15918/j.tbit1001-0645.2015.03.021

Isolation and structural identification of lignans from Dregea sinensis Hemsl

Shao Hua Jia, Fang Lü^*, Rong Ji Dai, Wei Wei Meng, Yan Chen, Yu Lin Deng

^*此作品的通讯作者

Beijing Institute of Technology

科研成果: 期刊稿件 › 文章 › 同行评审

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摘要

In order to study the chemical constituents of Dregea sinensis Hemsl, five lignans were isolated from the roots of Dregea sinensis Hemsl by AB-8 macroporous resin column, silica gel column, Sephadex LH-20 column and semi-preparative HPLC. On the basis of 1D and 2D NMR data and MS analyses, their structures were identified as 4', 4″-dihydroxy-3,3', 3″, 5,5', 5″-hexamethoxy-7,9':7',9-diepoxy-4,8″-oxy-8,8'-sesquineolignan-7″, 9″-diol (1), 4',4″-dihydroxy-3,3', 3″, 5, 5'-pentamethoxy-7,9':7', 9-diepoxy-4,8″-oxy-8,8'-sesquineo-lignan-7″, 9″-diol (2), (+)-isolariciresinol (3), erythro-guaiacylycerol-β-O-4'-coniferyl alcohol (4), diasyringaresinol (5). These compounds were isolated from this plant for the first time.

源语言	英语
页（从-至）	326-330
页数	5
期刊	Beijing Ligong Daxue Xuebao/Transaction of Beijing Institute of Technology
卷	35
期	3
DOI	https://doi.org/10.15918/j.tbit1001-0645.2015.03.021
出版状态	已出版 - 1 3月 2015

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Jia, S. H., Lü, F., Dai, R. J., Meng, W. W., Chen, Y., & Deng, Y. L. (2015). Isolation and structural identification of lignans from Dregea sinensis Hemsl. Beijing Ligong Daxue Xuebao/Transaction of Beijing Institute of Technology, 35(3), 326-330. https://doi.org/10.15918/j.tbit1001-0645.2015.03.021

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title = "Isolation and structural identification of lignans from Dregea sinensis Hemsl",

abstract = "In order to study the chemical constituents of Dregea sinensis Hemsl, five lignans were isolated from the roots of Dregea sinensis Hemsl by AB-8 macroporous resin column, silica gel column, Sephadex LH-20 column and semi-preparative HPLC. On the basis of 1D and 2D NMR data and MS analyses, their structures were identified as 4', 4″-dihydroxy-3,3', 3″, 5,5', 5″-hexamethoxy-7,9':7',9-diepoxy-4,8″-oxy-8,8'-sesquineolignan-7″, 9″-diol (1), 4',4″-dihydroxy-3,3', 3″, 5, 5'-pentamethoxy-7,9':7', 9-diepoxy-4,8″-oxy-8,8'-sesquineo-lignan-7″, 9″-diol (2), (+)-isolariciresinol (3), erythro-guaiacylycerol-β-O-4'-coniferyl alcohol (4), diasyringaresinol (5). These compounds were isolated from this plant for the first time.",

keywords = "Asclepiadaceae, Constituent, Dregea sinensis Hemsl, Lignans, Structure identification",

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AU - Deng, Yu Lin

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N2 - In order to study the chemical constituents of Dregea sinensis Hemsl, five lignans were isolated from the roots of Dregea sinensis Hemsl by AB-8 macroporous resin column, silica gel column, Sephadex LH-20 column and semi-preparative HPLC. On the basis of 1D and 2D NMR data and MS analyses, their structures were identified as 4', 4″-dihydroxy-3,3', 3″, 5,5', 5″-hexamethoxy-7,9':7',9-diepoxy-4,8″-oxy-8,8'-sesquineolignan-7″, 9″-diol (1), 4',4″-dihydroxy-3,3', 3″, 5, 5'-pentamethoxy-7,9':7', 9-diepoxy-4,8″-oxy-8,8'-sesquineo-lignan-7″, 9″-diol (2), (+)-isolariciresinol (3), erythro-guaiacylycerol-β-O-4'-coniferyl alcohol (4), diasyringaresinol (5). These compounds were isolated from this plant for the first time.

AB - In order to study the chemical constituents of Dregea sinensis Hemsl, five lignans were isolated from the roots of Dregea sinensis Hemsl by AB-8 macroporous resin column, silica gel column, Sephadex LH-20 column and semi-preparative HPLC. On the basis of 1D and 2D NMR data and MS analyses, their structures were identified as 4', 4″-dihydroxy-3,3', 3″, 5,5', 5″-hexamethoxy-7,9':7',9-diepoxy-4,8″-oxy-8,8'-sesquineolignan-7″, 9″-diol (1), 4',4″-dihydroxy-3,3', 3″, 5, 5'-pentamethoxy-7,9':7', 9-diepoxy-4,8″-oxy-8,8'-sesquineo-lignan-7″, 9″-diol (2), (+)-isolariciresinol (3), erythro-guaiacylycerol-β-O-4'-coniferyl alcohol (4), diasyringaresinol (5). These compounds were isolated from this plant for the first time.

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Isolation and structural identification of lignans from Dregea sinensis Hemsl

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