Integrated mueller-matrix near-infrared imaging and point-wise spectroscopy improves colonic cancer detection

Jianfeng Wang, Wei Zheng, Kan Lin, Zhiwei Huang

科研成果: 期刊稿件文章同行评审

25 引用 (Scopus)

摘要

We report the development and implementation of a unique integrated Mueller-matrix (MM) near-infrared (NIR) imaging and Muellermatrix point-wise diffuse reflectance (DR) spectroscopy technique for improving colonic cancer detection and diagnosis. Point-wise MM DR spectra can be acquired from any suspicious tissue areas indicated by MM imaging. A total of 30 paired colonic tissue specimens (normal vs. cancer) were measured using the integrated MM imaging and point-wise MM DR spectroscopy system. Polar decomposition algorithms are employed on the acquired images and spectra to derive three polarization metrics including depolarization, diattentuation and retardance for colonic tissue characterization. The decomposition results show that tissue depolarization and retardance are significantly decreased (p<0.001, paired 2-sided Student’s t-test, n = 30); while the tissue diattentuation is significantly increased (p<0.001, paired 2-sided Student’s t-test, n = 30) associated with colonic cancer. Further partial least squares discriminant analysis (PLS-DA) and leave-one tissue site-out, cross validation (LOSCV) show that the combination of the three polarization metrics provide the best diagnostic accuracy of 95.0% (sensitivity: 93.3%, and specificity: 96.7%) compared to either of the three polarization metrics (sensitivities of 93.3%, 83.3%, and 80.0%; and specificities of 90.0%, 96.7%, and 80.0%, respectively, for the depolarization, diattentuation and retardance metrics) for colonic cancer detection. This work suggests that the integrated MM NIR imaging and point-wise MM NIR diffuse reflectance spectroscopy has the potential to improve the early detection and diagnosis of malignant lesions in the colon.

源语言英语
页(从-至)1116-1126
页数11
期刊Biomedical Optics Express
7
4
DOI
出版状态已出版 - 3 3月 2016
已对外发布

指纹

探究 'Integrated mueller-matrix near-infrared imaging and point-wise spectroscopy improves colonic cancer detection' 的科研主题。它们共同构成独一无二的指纹。

引用此