Influence of pulse repetition rate on singlet oxygen production during photosensitization using a pulsed laser

Defu Chen; Ying Wang; Buhong Li; Ying Gu

Influence of pulse repetition rate on singlet oxygen production during photosensitization using a pulsed laser

Defu Chen, Ying Wang, Buhong Li, Ying Gu^*

^*此作品的通讯作者

医学技术学院

科研成果: 期刊稿件 › 文章 › 同行评审

摘要

Pulsed lasers have been widely applied in photodynamic therapy (PDT). However, the effects of pulsed laser parameters on PDT efficacy have not been fully understood. Singlet oxygen (1O2) is known to be a major cytotoxic agent in PDT. In this study, the influence of pulse repetition rate on 1O2 production was evaluated by detecting 1O2 luminescence at 1270 nm. We studied the generation of 1O2 using a pulsed laser by changing its repetition rate (1-90 kHz). The results showed that there was no significant difference in 1O2 production among different repetition rates with the same irradiation power of 20 mW.

源语言	英语
页（从-至）	312-314
页数	3
期刊	Photonics and Lasers in Medicine
卷	4
期	4
出版状态	已出版 - 1 11月 2015

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Chen, D., Wang, Y., Li, B., & Gu, Y. (2015). Influence of pulse repetition rate on singlet oxygen production during photosensitization using a pulsed laser. Photonics and Lasers in Medicine, 4(4), 312-314.

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title = "Influence of pulse repetition rate on singlet oxygen production during photosensitization using a pulsed laser",

abstract = "Pulsed lasers have been widely applied in photodynamic therapy (PDT). However, the effects of pulsed laser parameters on PDT efficacy have not been fully understood. Singlet oxygen (1O2) is known to be a major cytotoxic agent in PDT. In this study, the influence of pulse repetition rate on 1O2 production was evaluated by detecting 1O2 luminescence at 1270 nm. We studied the generation of 1O2 using a pulsed laser by changing its repetition rate (1-90 kHz). The results showed that there was no significant difference in 1O2 production among different repetition rates with the same irradiation power of 20 mW.",

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T1 - Influence of pulse repetition rate on singlet oxygen production during photosensitization using a pulsed laser

AU - Chen, Defu

AU - Wang, Ying

AU - Li, Buhong

AU - Gu, Ying

PY - 2015/11/1

Y1 - 2015/11/1

N2 - Pulsed lasers have been widely applied in photodynamic therapy (PDT). However, the effects of pulsed laser parameters on PDT efficacy have not been fully understood. Singlet oxygen (1O2) is known to be a major cytotoxic agent in PDT. In this study, the influence of pulse repetition rate on 1O2 production was evaluated by detecting 1O2 luminescence at 1270 nm. We studied the generation of 1O2 using a pulsed laser by changing its repetition rate (1-90 kHz). The results showed that there was no significant difference in 1O2 production among different repetition rates with the same irradiation power of 20 mW.

AB - Pulsed lasers have been widely applied in photodynamic therapy (PDT). However, the effects of pulsed laser parameters on PDT efficacy have not been fully understood. Singlet oxygen (1O2) is known to be a major cytotoxic agent in PDT. In this study, the influence of pulse repetition rate on 1O2 production was evaluated by detecting 1O2 luminescence at 1270 nm. We studied the generation of 1O2 using a pulsed laser by changing its repetition rate (1-90 kHz). The results showed that there was no significant difference in 1O2 production among different repetition rates with the same irradiation power of 20 mW.

KW - Luminescence

KW - Photodynamic therapy

KW - Pulse repetition rate.

KW - Pulsed laser

KW - Singlet oxygen

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Influence of pulse repetition rate on singlet oxygen production during photosensitization using a pulsed laser

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