In vivo guiding nitrogen-doped carbon nanozyme for tumor catalytic therapy

Kelong Fan, Juqun Xi, Lei Fan, Peixia Wang, Chunhua Zhu, Yan Tang, Xiangdong Xu, Minmin Liang, Bing Jiang, Xiyun Yan*, Lizeng Gao

*此作品的通讯作者

科研成果: 期刊稿件文章同行评审

834 引用 (Scopus)

摘要

Nanomaterials with intrinsic enzyme-like activities (nanozymes), have been widely used as artificial enzymes in biomedicine. However, how to control their in vivo performance in a target cell is still challenging. Here we report a strategy to coordinate nanozymes to target tumor cells and selectively perform their activity to destruct tumors. We develop a nanozyme using nitrogen-doped porous carbon nanospheres which possess four enzyme-like activities (oxidase, peroxidase, catalase and superoxide dismutase) responsible for reactive oxygen species regulation. We then introduce ferritin to guide nitrogen-doped porous carbon nanospheres into lysosomes and boost reactive oxygen species generation in a tumor-specific manner, resulting in significant tumor regression in human tumor xenograft mice models. Together, our study provides evidence that nitrogen-doped porous carbon nanospheres are powerful nanozymes capable of regulating intracellular reactive oxygen species, and ferritinylation is a promising strategy to render nanozymes to target tumor cells for in vivo tumor catalytic therapy.

源语言英语
文章编号1440
期刊Nature Communications
9
1
DOI
出版状态已出版 - 1 12月 2018
已对外发布

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Fan, K., Xi, J., Fan, L., Wang, P., Zhu, C., Tang, Y., Xu, X., Liang, M., Jiang, B., Yan, X., & Gao, L. (2018). In vivo guiding nitrogen-doped carbon nanozyme for tumor catalytic therapy. Nature Communications, 9(1), 文章 1440. https://doi.org/10.1038/s41467-018-03903-8