摘要
In this paper, we presented a method to improve structural modeling based on conserved domain clusters and structure-anchored alignments. We first constructed a template library of structural clusters for all conserved sequence domains. Then, for each cluster, we built the profile using the structure and sequence information. Finally we use the profile and structural alignments as anchors to increase the alignment accuracy between a query and its templates. Our preliminary results show that this method can be used for the partial prediction for a majority of known protein sequences with better qualities.
| 源语言 | 英语 |
|---|---|
| 主期刊名 | Proceedings of the 2007 ACM Symposium on Applied Computing |
| 出版商 | Association for Computing Machinery |
| 页 | 128-132 |
| 页数 | 5 |
| ISBN（印刷版） | 1595934804, 9781595934802 |
| DOI | |
| 出版状态 | 已出版 - 2007 |
| 已对外发布 | 是 |
| 活动 | 2007 ACM Symposium on Applied Computing - Seoul, 韩国 期限: 11 3月 2007 → 15 3月 2007 |
出版系列
| 姓名 | Proceedings of the ACM Symposium on Applied Computing |
|---|
会议
| 会议 | 2007 ACM Symposium on Applied Computing |
|---|---|
| 国家/地区 | 韩国 |
| 市 | Seoul |
| 时期 | 11/03/07 → 15/03/07 |
指纹
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Zhang, F., Xu, L., Liu, Z., & Yuan, B. (2007). Improved structural modeling based on conserved domain clusters and structure-anchored alignments. 在 Proceedings of the 2007 ACM Symposium on Applied Computing (页码 128-132). (Proceedings of the ACM Symposium on Applied Computing). Association for Computing Machinery. https://doi.org/10.1145/1244002.1244033