摘要
Mesenchymal niche cells instruct activity of tissue-resident stem and progenitor cell populations. Epithelial stem cells in hair follicles (HFs) have region-specific activity, which may arise from intrinsic cellular heterogeneity within mesenchymal dermal papilla (DP) cells. Here we show that expression of Hoxc genes is sufficient to reprogram mesenchymal DP cells and alter the regenerative potential of epithelial stem cells. Hoxc gene expression in adult skin dermis closely correlates with regional HF regeneration patterns. Disrupting the region-specific expression patterns of Hoxc genes, by either decreasing their epigenetic repression via Bmi1 loss or inducing ectopic interactions of the Hoxc locus with an active epigenetic region, leads to precocious HF regeneration. We further show that a single Hoxc gene is sufficient to activate dormant DP niches and promote regional HF regeneration through canonical Wnt signaling. Altogether, these results reveal that Hoxc genes bestow mesenchymal niches with tissue-level heterogeneity and plasticity. Yu et al. show that Hoxc gene expression in mesenchymal niches controls epithelial stem cell activation via Wnt signaling. Hoxc expression patterns vary at the tissue level, suggesting that the regenerative landscape of the skin is governed by mesenchymal niche plasticity.
源语言 | 英语 |
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页(从-至) | 487-500.e6 |
期刊 | Cell Stem Cell |
卷 | 23 |
期 | 4 |
DOI | |
出版状态 | 已出版 - 4 10月 2018 |
已对外发布 | 是 |