Hoxc-Dependent Mesenchymal Niche Heterogeneity Drives Regional Hair Follicle Regeneration

Zhou Yu, Kaiju Jiang, Zijian Xu, Huanwei Huang, Nannan Qian, Zhiwei Lu, Daoming Chen, Ruonan Di, Tianyi Yuan, Zhenhai Du, Wei Xie, Xiaoling Lu, Huawei Li, Renjie Chai, Yong Yang, Bing Zhu, Tetsuo Kunieda, Fengchao Wang*, Ting Chen

*此作品的通讯作者

科研成果: 期刊稿件文章同行评审

47 引用 (Scopus)

摘要

Mesenchymal niche cells instruct activity of tissue-resident stem and progenitor cell populations. Epithelial stem cells in hair follicles (HFs) have region-specific activity, which may arise from intrinsic cellular heterogeneity within mesenchymal dermal papilla (DP) cells. Here we show that expression of Hoxc genes is sufficient to reprogram mesenchymal DP cells and alter the regenerative potential of epithelial stem cells. Hoxc gene expression in adult skin dermis closely correlates with regional HF regeneration patterns. Disrupting the region-specific expression patterns of Hoxc genes, by either decreasing their epigenetic repression via Bmi1 loss or inducing ectopic interactions of the Hoxc locus with an active epigenetic region, leads to precocious HF regeneration. We further show that a single Hoxc gene is sufficient to activate dormant DP niches and promote regional HF regeneration through canonical Wnt signaling. Altogether, these results reveal that Hoxc genes bestow mesenchymal niches with tissue-level heterogeneity and plasticity. Yu et al. show that Hoxc gene expression in mesenchymal niches controls epithelial stem cell activation via Wnt signaling. Hoxc expression patterns vary at the tissue level, suggesting that the regenerative landscape of the skin is governed by mesenchymal niche plasticity.

源语言英语
页(从-至)487-500.e6
期刊Cell Stem Cell
23
4
DOI
出版状态已出版 - 4 10月 2018
已对外发布

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