TY - GEN
T1 - High-Throughput Microchannels for Single Cell Immobilization
AU - Tang, Xiaoqing
AU - Liu, Xiaoming
AU - Li, Pengyun
AU - Lin, Yuqing
AU - Huang, Qiang
AU - Tatsuo, Arai
N1 - Publisher Copyright:
© 2018 IEEE.
PY - 2018/12/18
Y1 - 2018/12/18
N2 - Nowadays single cell analysis becomes a more and more important method to gather the information of individual cells and study the heterogeneity of cells caused by random expression of gene, protein and the level of metabolism. Many device and technologies of single cell analysis have been developed to meet these needs. In this paper, we presented a high-throughput microchannel for single cell immobilization with small sheer pressure. It features high density arrays, which can accommodate up to 130∼300 traps within 1∼2 mm 2 . According to our experiment, about 91% of capture unit can be occupied by the single cell in 40 s, using the optimized structure of microchannels. Therefore, we expect that the high throughput microchannels can be of great importance for the biological research.
AB - Nowadays single cell analysis becomes a more and more important method to gather the information of individual cells and study the heterogeneity of cells caused by random expression of gene, protein and the level of metabolism. Many device and technologies of single cell analysis have been developed to meet these needs. In this paper, we presented a high-throughput microchannel for single cell immobilization with small sheer pressure. It features high density arrays, which can accommodate up to 130∼300 traps within 1∼2 mm 2 . According to our experiment, about 91% of capture unit can be occupied by the single cell in 40 s, using the optimized structure of microchannels. Therefore, we expect that the high throughput microchannels can be of great importance for the biological research.
UR - http://www.scopus.com/inward/record.url?scp=85060794898&partnerID=8YFLogxK
U2 - 10.1109/ICARCV.2018.8581306
DO - 10.1109/ICARCV.2018.8581306
M3 - Conference contribution
AN - SCOPUS:85060794898
T3 - 2018 15th International Conference on Control, Automation, Robotics and Vision, ICARCV 2018
SP - 103
EP - 107
BT - 2018 15th International Conference on Control, Automation, Robotics and Vision, ICARCV 2018
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 15th International Conference on Control, Automation, Robotics and Vision, ICARCV 2018
Y2 - 18 November 2018 through 21 November 2018
ER -