GSH/pH dual-activated POM@MOF for tumor cell-specific synergistic photothermal and chemodynamic therapy

Bole Li, Zhujun Wu, Xiaotong Xu, Yanfei Lv, Yunfei Guo, Siyu Liang, Zhimin Wang*, Lei He*, Yu Fei Song*

*此作品的通讯作者

科研成果: 期刊稿件文章同行评审

5 引用 (Scopus)

摘要

Photothermal therapy (PTT) is emerging as a promising therapeutic approach for tumor treatment. However, the low therapeutic effect of photothermal agents due to their non-specificity and the monotherapy approach remains challenging for further applications. Herein, tumor microenvironment (TME) specifically responsive POM@MOF composites with sequential activation properties were constructed by encapsulating POMs (PMo12, short for H3PMo12O40) into metal organic framework (MIL-101) carriers for synergistic PTT/chemodynamic therapy (CDT) treatment. PMo12@MIL-101 releases PMo12 and Fe3+ under acidic TME conditions, which are subsequently converted into reduced PMo12 and Fe2+ by GSH in the TME. PMo12 in its reduced state exhibits excellent photothermal conversion efficiency (47.03%) under near-infrared laser irradiation, which boosts the CDT effects by accelerating the reaction between H2O2 and Fe2+ and producing more ˙OH radicals. The resulting PTT/CDT synergistic therapeutic effects are highly dependent on the pH value and GSH concentration in the TME, and exhibit a strong inhibition of HepG2 cell proliferation compared to monotherapy.

源语言英语
页(从-至)4439-4448
页数10
期刊Inorganic Chemistry Frontiers
11
14
DOI
出版状态已出版 - 11 6月 2024

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Li, B., Wu, Z., Xu, X., Lv, Y., Guo, Y., Liang, S., Wang, Z., He, L., & Song, Y. F. (2024). GSH/pH dual-activated POM@MOF for tumor cell-specific synergistic photothermal and chemodynamic therapy. Inorganic Chemistry Frontiers, 11(14), 4439-4448. https://doi.org/10.1039/d4qi01079e