Free Radical Cyclization of N -Arylacrylamides: Mild and Facile Synthesis of 3-Thiocyanato Oxindoles

Pran Gopal Karmaker, Jiashen Qiu, Di Wu, Hongquan Yin, Fu Xue Chen*

*此作品的通讯作者

科研成果: 期刊稿件文章同行评审

19 引用 (Scopus)

摘要

A novel and convenient oxidative radical cyclization of N-substituted N -arylacrylamides for the synthesis of 3-thiocyanated oxindoles has been developed by using AgSCN and K 2 S 2 O 8 as the radical source. This process allows a consistent and convenient access to SCN-containing heterocycles bearing a broad range of functional groups in good to excellent yields (up to 91%). Moreover, the use of inexpensive and readily available starting materials, operational simplicity, and excellent functional group tolerance makes this protocol practically attractive.

源语言英语
文章编号st-2017-w0859-l
页(从-至)954-958
页数5
期刊Synlett
29
7
DOI
出版状态已出版 - 23 4月 2018

指纹

探究 'Free Radical Cyclization of N -Arylacrylamides: Mild and Facile Synthesis of 3-Thiocyanato Oxindoles' 的科研主题。它们共同构成独一无二的指纹。

引用此