TY - GEN
T1 - Fragmentation pattern of glycated peptides derived from D-glucose by tandem mass spectrometry
AU - Su, Rui
AU - Liu, Yahui
AU - Wang, Yun
AU - Zhang, Yongqian
AU - Hong, Qing
AU - Deng, Yulin
PY - 2013
Y1 - 2013
N2 - Evidence shows that non-enzymatic glycation plays an important role in the development of diabetes, diabetes-related complications and neurodegenerative diseases. Mass spectrometric methods have been used for non-enzymatic glycation of proteins. At present, CID remains the major fragmentation method for peptide sequencing. In this study, we utilized synthesized peptide models to study fragmentation spectra of glycated peptides, which can be easily studied using ESI-MS. MS/MS fragmentation whose characteristics of glycated peptides will help for large-scale glycated proteomics analyses of complex plasma and tissue samples.
AB - Evidence shows that non-enzymatic glycation plays an important role in the development of diabetes, diabetes-related complications and neurodegenerative diseases. Mass spectrometric methods have been used for non-enzymatic glycation of proteins. At present, CID remains the major fragmentation method for peptide sequencing. In this study, we utilized synthesized peptide models to study fragmentation spectra of glycated peptides, which can be easily studied using ESI-MS. MS/MS fragmentation whose characteristics of glycated peptides will help for large-scale glycated proteomics analyses of complex plasma and tissue samples.
KW - CID
KW - Fragmentation
KW - Non-enzymatic glycation
KW - neutral loss
UR - http://www.scopus.com/inward/record.url?scp=84881501559&partnerID=8YFLogxK
U2 - 10.1109/ICCME.2013.6548298
DO - 10.1109/ICCME.2013.6548298
M3 - Conference contribution
AN - SCOPUS:84881501559
SN - 9781467329699
T3 - 2013 ICME International Conference on Complex Medical Engineering, CME 2013
SP - 493
EP - 496
BT - 2013 ICME International Conference on Complex Medical Engineering, CME 2013
T2 - 2013 7th ICME International Conference on Complex Medical Engineering, CME 2013
Y2 - 25 May 2013 through 28 May 2013
ER -
