Flexible Synthesis of Benzofuranones from ortho-Alkynyl Phenols or Benzofurans

Wenqian Du; Rongjie Yang; Jiawen Wu; Zhonghua Xia

doi:10.1002/ejoc.202201497

Flexible Synthesis of Benzofuranones from ortho-Alkynyl Phenols or Benzofurans

Wenqian Du, Rongjie Yang, Jiawen Wu, Zhonghua Xia^*

^*此作品的通讯作者

材料学院

Beijing Institute of Technology

科研成果: 期刊稿件 › 文章 › 同行评审

8 引用（Scopus）

摘要

Benzofuranones are attractive synthetic targets in medicinal and natural products. The cycloisomerization of o-alkynyl phenol to benzofuran-3(2H)-one is reported here using gold(I) and Selectfluor. This benzofuranone can also be obtained from benzofuran without a gold catalyst. This study presents two appealing synthetic methods for benzofuran-3(2H)-ones that use readily available starting materials, have high chemoselectivity and operate under very mild conditions.

源语言	英语
文章编号	e202201497
期刊	European Journal of Organic Chemistry
卷	26
期	8
DOI	https://doi.org/10.1002/ejoc.202201497
出版状态	已出版 - 17 2月 2023

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Du, W., Yang, R., Wu, J., & Xia, Z. (2023). Flexible Synthesis of Benzofuranones from ortho-Alkynyl Phenols or Benzofurans. European Journal of Organic Chemistry, 26(8), 文章 e202201497. https://doi.org/10.1002/ejoc.202201497

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AU - Xia, Zhonghua

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AB - Benzofuranones are attractive synthetic targets in medicinal and natural products. The cycloisomerization of o-alkynyl phenol to benzofuran-3(2H)-one is reported here using gold(I) and Selectfluor. This benzofuranone can also be obtained from benzofuran without a gold catalyst. This study presents two appealing synthetic methods for benzofuran-3(2H)-ones that use readily available starting materials, have high chemoselectivity and operate under very mild conditions.

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Flexible Synthesis of Benzofuranones from ortho-Alkynyl Phenols or Benzofurans

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