Enzyme immobilization in a Ru(N^N)3-modified covalent organic framework for photoenzymatic cascade catalysis

Yanxia Wang, Bingchen Guo, Zhihua Chai, Ming Gao, Yanlin Li, Yang Yu*, Shengli Huang*

*此作品的通讯作者

科研成果: 期刊稿件文章同行评审

摘要

The co-immobilization of enzymes and metal catalysts addresses key challenges in chemo-enzymatic catalysis, leading to a more efficient and environmentally sustainable process. Central to this approach is the development of a solid support with large pore size and an efficient decoration method for both enzymes and metal catalysts. In this context, a mesoporous covalent organic framework is rationally designed as the porous solid carrier for co-immobilizing a Ru(N^N)3-based photocatalyst, a Cp*Rh-based electron mediator, and an alcohol dehydrogenase. The integrated system catalyzes the Michael addition between 1-propanethiol and 1-penten-3-one to produce 1-(propylthio)pentan-3-one under visible light irradiation, which is further reduced to 1-(propylthio)pentan-3-ol with a photo-regenerated nicotinamide cofactor. This work presents a novel one-pot photobiocatalytic cascade system for synthesizing enantiomerically pure 1,3-mercaptoalkanols. The system showcases excellent performance in terms of yield and enantioselectivity, along with effective cofactor photo-regeneration, demonstrating a significant advancement in the field of chemo-enzymatic catalysis through enzyme and metal catalyst co-immobilization.

源语言英语
页(从-至)18537-18543
页数7
期刊Journal of Materials Chemistry A
12
29
DOI
出版状态已出版 - 16 6月 2024

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