Engineering Oncolytic Adenoviruses with VSVG-Decorated Tumor Cell Membranes for Synergistically Enhanced Antitumor Therapy

Li Li Huang, Weiwei Wang, Zhongjie Wang, Han Zhang, Houli Liu, Guanghao Wu, Weidong Nie, Hai Yan Xie*

*此作品的通讯作者

科研成果: 期刊稿件文章同行评审

5 引用 (Scopus)

摘要

Oncolytic viruses hold great promise for cancer treatment but their practical applications are seriously impaired by a series of limitations. Herein, an engineered oncolytic adenovirus (OA) is constructed that can boost both the direct oncolysis and antitumor immune response of OA attributed to the increased tumor targeting and low-pH responsive fusogenic activity. The tumor cell membranes are decorated with vesicular stomatitis virus glycoprotein (VSVG) via vesicular stomatitis virus (VSV) infection and then used to mask OA (V-M@OA). After systemic administration, the engineered OA can target homologous tumors owing to the homing ability of tumor membranes. Then the unique low-pH responsive fusogenic activity of VSVG significantly enhances the replication of OA by promoting the whole virus infection process, resulting in remarkable virus-mediated tumoricidal effects and thus abundant in situ released tumor-associated antigens (TAAs). Meanwhile, VSVG on V-M@OA augments the adjuvanticity of OA and thus significantly enhancing the antitumor immune response. The synergism of virus-mediated killing and immune effects leads to significant tumor inhibition with no obvious side effects.

源语言英语
文章编号2209056
期刊Advanced Functional Materials
33
3
DOI
出版状态已出版 - 16 1月 2023

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