Enantioselective synthesis of trifluoromethylated tertiary thioethers through organocatalytic sulfa-Michael addition of thiols to β-trifluoromethyl β,β-disubstituted enones

Yao Feng Wang, Shaoxiang Wu, Pran Gopal Karmaker, Muhammad Sohail, Qi Wang, Fu Xue Chen*

*此作品的通讯作者

科研成果: 期刊稿件文章同行评审

14 引用 (Scopus)

摘要

An organocatalytic asymmetric sulfa-Michael addition of thiols to β-trifluoromethyl β,β-disubstituted (E)-enones in the presence of 10 mol% of a cinchona alkaloid-derived thiourea catalyst provides direct and simple access to chiral trifluoromethyl tertiary thioethers in high yields and up to 76% ee.

源语言英语
页(从-至)1147-1153
页数7
期刊Synthesis
47
8
DOI
出版状态已出版 - 1 4月 2015

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