Enantioselective electrophilic cyanation of β-keto amides catalysed by a cinchona organocatalyst

Pran Gopal Karmaker, Jiashen Qiu, Di Wu, Mengmeng Reng, Zhuo Yang, Hongquan Yin, Fu Xue Chen*

*此作品的通讯作者

科研成果: 期刊稿件文章同行评审

7 引用 (Scopus)

摘要

An operationally simple protocol for the enantioselective electrophilic α-cyanation of β-keto amides catalyzed by cinchona-derived catalysts has been demonstrated. The resulting products could be obtained with good to high enantioselectivities (up to 88% ee) and with excellent yields (up to 94%) by employing the mild active 4-acetylphenyl cyanate as the cationic cyano source in the catalytic asymmetric α-cyanation reaction.

源语言英语
页(从-至)7753-7757
页数5
期刊Organic and Biomolecular Chemistry
15
37
DOI
出版状态已出版 - 2017

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