摘要
An operationally simple protocol for the enantioselective electrophilic α-cyanation of β-keto amides catalyzed by cinchona-derived catalysts has been demonstrated. The resulting products could be obtained with good to high enantioselectivities (up to 88% ee) and with excellent yields (up to 94%) by employing the mild active 4-acetylphenyl cyanate as the cationic cyano source in the catalytic asymmetric α-cyanation reaction.
源语言 | 英语 |
---|---|
页(从-至) | 7753-7757 |
页数 | 5 |
期刊 | Organic and Biomolecular Chemistry |
卷 | 15 |
期 | 37 |
DOI | |
出版状态 | 已出版 - 2017 |