TY - JOUR
T1 - Effective chemical constituent's confirmation of extracting solution from herbs and their gene targets
AU - Jin, Wen
AU - Deng, Qingqiong
AU - Niu, Meiying
AU - Hu, Liping
AU - Liu, Aijuan
AU - Tian, Guihua
AU - Lu, Jianqiu
AU - Zhou, Mingquan
AU - Murtaza, Ghulam
AU - Jiang, Haiyan
PY - 2014
Y1 - 2014
N2 - Ixeris sonchifolia Hance, a normal perennial herb, has effects on appendicitis, headache, menstruation, blood circulation, blood stasis, pain, fibrinolytic enzymes, thrombus formation, coronary artery, myocardial infarct size, PGI2, ET, TXA2, TNF-,αIL-6 and IL-8, etc . However, there was no full coverage about the molecular basis and gene targets of Ixeris sonchifolia injection. PubChem Database and DAVID Database had been used conjunctively to detect the gene IDs, gene targets and their functions. There were 3008 genes found in the final results, 16 kinds of definite functions had been detected, 9 of which had been proved and the effects were focused on the psychological, immune, neurological, metabolic, cardiovascular and cancer functions. Ixeris sonchifolia had a wide effects on various symptoms, which had been reported by previous experiments and verified by this research; however its influences on aging, chemdependency, developmental, normalvariation, reproduction, pharmacogenomic and psychologic functions should be confirmed in the future experiments.
AB - Ixeris sonchifolia Hance, a normal perennial herb, has effects on appendicitis, headache, menstruation, blood circulation, blood stasis, pain, fibrinolytic enzymes, thrombus formation, coronary artery, myocardial infarct size, PGI2, ET, TXA2, TNF-,αIL-6 and IL-8, etc . However, there was no full coverage about the molecular basis and gene targets of Ixeris sonchifolia injection. PubChem Database and DAVID Database had been used conjunctively to detect the gene IDs, gene targets and their functions. There were 3008 genes found in the final results, 16 kinds of definite functions had been detected, 9 of which had been proved and the effects were focused on the psychological, immune, neurological, metabolic, cardiovascular and cancer functions. Ixeris sonchifolia had a wide effects on various symptoms, which had been reported by previous experiments and verified by this research; however its influences on aging, chemdependency, developmental, normalvariation, reproduction, pharmacogenomic and psychologic functions should be confirmed in the future experiments.
KW - Database
KW - Functions
KW - Gene targets
KW - Information integration
KW - Ixeris sonchifolia hance
UR - http://www.scopus.com/inward/record.url?scp=84900341185&partnerID=8YFLogxK
U2 - 10.2298/GENSR1401075J
DO - 10.2298/GENSR1401075J
M3 - Article
AN - SCOPUS:84900341185
SN - 0534-0012
VL - 46
SP - 75
EP - 94
JO - Genetika
JF - Genetika
IS - 1
ER -