TY - JOUR
T1 - Dysregulation of Transcription Factors
T2 - A Key Culprit Behind Neurodegenerative Disorders
AU - Jin, Wei
AU - Qazi, Talal Jamil
AU - Quan, Zhenzhen
AU - Li, Nuomin
AU - Qing, Hong
N1 - Publisher Copyright:
© The Author(s) 2018.
PY - 2019/12/1
Y1 - 2019/12/1
N2 - Neurodegenerative diseases (NDs) are considered heterogeneous disorders characterized by progressive pathological changes in neuronal systems. Transcription factors are protein molecules that are important in regulating the expression of genes. Although the clinical manifestations of NDs vary, the pathological processes appear similar with regard to neuroinflammation, oxidative stress, and proteostasis, to which, as numerous studies have discovered, transcription factors are closely linked. In this review, we summarized and reviewed the roles of transcription factors in NDs, and then we elucidated their functions during pathological processes, and finally we discussed their therapeutic values in NDs.
AB - Neurodegenerative diseases (NDs) are considered heterogeneous disorders characterized by progressive pathological changes in neuronal systems. Transcription factors are protein molecules that are important in regulating the expression of genes. Although the clinical manifestations of NDs vary, the pathological processes appear similar with regard to neuroinflammation, oxidative stress, and proteostasis, to which, as numerous studies have discovered, transcription factors are closely linked. In this review, we summarized and reviewed the roles of transcription factors in NDs, and then we elucidated their functions during pathological processes, and finally we discussed their therapeutic values in NDs.
KW - mitochondrial dysfunction
KW - neurodegenerative disorders
KW - proteostasis
KW - stress response
KW - transcription factors
KW - transcription factors’ dysregulations
UR - http://www.scopus.com/inward/record.url?scp=85059050954&partnerID=8YFLogxK
U2 - 10.1177/1073858418811787
DO - 10.1177/1073858418811787
M3 - Review article
C2 - 30484370
AN - SCOPUS:85059050954
SN - 1073-8584
VL - 25
SP - 548
EP - 565
JO - Neuroscientist
JF - Neuroscientist
IS - 6
ER -