Dysregulation of Transcription Factors: A Key Culprit Behind Neurodegenerative Disorders

Wei Jin, Talal Jamil Qazi, Zhenzhen Quan, Nuomin Li*, Hong Qing

*此作品的通讯作者

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8 引用 (Scopus)

摘要

Neurodegenerative diseases (NDs) are considered heterogeneous disorders characterized by progressive pathological changes in neuronal systems. Transcription factors are protein molecules that are important in regulating the expression of genes. Although the clinical manifestations of NDs vary, the pathological processes appear similar with regard to neuroinflammation, oxidative stress, and proteostasis, to which, as numerous studies have discovered, transcription factors are closely linked. In this review, we summarized and reviewed the roles of transcription factors in NDs, and then we elucidated their functions during pathological processes, and finally we discussed their therapeutic values in NDs.

源语言英语
页(从-至)548-565
页数18
期刊Neuroscientist
25
6
DOI
出版状态已出版 - 1 12月 2019

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Jin, W., Qazi, T. J., Quan, Z., Li, N., & Qing, H. (2019). Dysregulation of Transcription Factors: A Key Culprit Behind Neurodegenerative Disorders. Neuroscientist, 25(6), 548-565. https://doi.org/10.1177/1073858418811787