@inproceedings{5e6ba9728a5a43b3a666ca095dc17769,
title = "Disease candidate gene identification and gene regulatory network building through medical literature mining",
abstract = "Finding key genes associated with diseases is an essential problem of disease diagnosis and treatment, and drug design. Bioinformatics takes advantage of computer technology to analyze biomedical data to help finding the information about these genes. Biomedical literatures, which consists of original experimental data and results, are attracting more attention from bio-informatics researchers because literature mining technology can extract knowledge more efficiently. This paper designs an algorithm to estimate the association degree between genes according to their co-citations in biomedical literatures from PubMed database, and to further predict the causative genes associated with a disease. The paper also uses hierarchical clustering algorithm to build a specific genes regulation network. Experiments on uterine cancer shows that the proposed algorithm can identify pathogenic genes of uterine cancer accurately and rapidly.",
keywords = "Co-citation, Gene regulatory network, Hierarchical clustering, Literature mining, Pathogenic gene",
author = "Yong Wang and Chenyang Jiang and Jinbiao Cheng and Xiaoqun Wang",
note = "Publisher Copyright: {\textcopyright} Springer International Publishing Switzerland 2017.; International Conference on Information Technology and Intelligent Transportation Systems, ITITS 2015 ; Conference date: 12-12-2015 Through 13-12-2015",
year = "2017",
doi = "10.1007/978-3-319-38771-0_44",
language = "English",
isbn = "9783319387697",
series = "Advances in Intelligent Systems and Computing",
publisher = "Springer Verlag",
pages = "453--461",
editor = "Jain, {Lakhmi C.} and Xiangmo Zhao and Balas, {Valentina Emilia}",
booktitle = "Information Technology and Intelligent Transportation System - Volume 2, Proceedings of the International Conference on Information Technology and Intelligent Transportation Systems, ITITS 2015",
address = "Germany",
}