Disease candidate gene identification and gene regulatory network building through medical literature mining

Yong Wang*, Chenyang Jiang, Jinbiao Cheng, Xiaoqun Wang

*此作品的通讯作者

科研成果: 书/报告/会议事项章节会议稿件同行评审

摘要

Finding key genes associated with diseases is an essential problem of disease diagnosis and treatment, and drug design. Bioinformatics takes advantage of computer technology to analyze biomedical data to help finding the information about these genes. Biomedical literatures, which consists of original experimental data and results, are attracting more attention from bio-informatics researchers because literature mining technology can extract knowledge more efficiently. This paper designs an algorithm to estimate the association degree between genes according to their co-citations in biomedical literatures from PubMed database, and to further predict the causative genes associated with a disease. The paper also uses hierarchical clustering algorithm to build a specific genes regulation network. Experiments on uterine cancer shows that the proposed algorithm can identify pathogenic genes of uterine cancer accurately and rapidly.

源语言英语
主期刊名Information Technology and Intelligent Transportation System - Volume 2, Proceedings of the International Conference on Information Technology and Intelligent Transportation Systems, ITITS 2015
编辑Lakhmi C. Jain, Xiangmo Zhao, Valentina Emilia Balas
出版商Springer Verlag
453-461
页数9
ISBN(印刷版)9783319387697
DOI
出版状态已出版 - 2017
活动International Conference on Information Technology and Intelligent Transportation Systems, ITITS 2015 - Xi’an, 中国
期限: 12 12月 201513 12月 2015

出版系列

姓名Advances in Intelligent Systems and Computing
455
ISSN(印刷版)2194-5357

会议

会议International Conference on Information Technology and Intelligent Transportation Systems, ITITS 2015
国家/地区中国
Xi’an
时期12/12/1513/12/15

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