Development of a miniature mass spectrometer with continuous atmospheric pressure interface

Yanbing Zhai, Yan Feng, Yongzheng Wei, Yuzhuo Wang, Wei Xu*

*此作品的通讯作者

科研成果: 期刊稿件文章同行评审

112 引用 (Scopus)

摘要

The demand for on-the-spot analysis is met by a miniature mass spectrometer which is preferred to be robust, stable, as small as possible and capable of analyzing different samples by coupling with various ionization methods. However, largely constrained by the atmospheric pressure interface (API), these aspects are difficult to be realized in one system. Herein, we describe the development of a new miniature mass spectrometer with balanced performance. The miniature mass spectrometer is small in size (30 × 30 × 18 cm) but has a continuous API, which was achieved by high-pressure ion trap operation and maximized ion transfer efficiency with the utilization of a differential pumping system. The miniature mass spectrometer was characterized and optimized in terms of stability, sensitivity, mass range, mass resolution and scan speed. Rapid analysis of mixtures was demonstrated by coupling the miniature mass spectrometer with the ambient ionization technique of paper spray. This is the smallest miniature mass spectrometer to date, which has a continuous API.

源语言英语
页(从-至)3406-3414
页数9
期刊The Analyst
140
10
DOI
出版状态已出版 - 21 5月 2015

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