Copper(i)-catalyzed electrophilic thiocyanation/dearomatization/spirocyclization of benzofurans to synthesize benzannulated spiroketals

Ying He, Qing Wang, Hongquan Yin, Fu Xue Chen*

*此作品的通讯作者

科研成果: 期刊稿件文章同行评审

1 引用 (Scopus)

摘要

A Lewis acid-catalyzed electrophilic dearomatizative thiocyanation and cyclization of benzofurans with N-thiocyanatosuccinimide has been accomplished by Lewis acid catalysis with CuOTf under mild conditions. It was suggested that the electrophilic thiocyanating reagent was activated by CuOTf, and difunctionalization was achieved through a thiocyanation/spirocyclization pathway. Thus, a series of thiocyanato-containing spiroketals were obtained in moderate to high yields. It provides an alternative approach for the synthesis of functionalized [6,5]/[5,5]-spiroketals.

源语言英语
页(从-至)4216-4219
页数4
期刊Organic and Biomolecular Chemistry
21
20
DOI
出版状态已出版 - 3 5月 2023

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