摘要
A Lewis acid-catalyzed electrophilic dearomatizative thiocyanation and cyclization of benzofurans with N-thiocyanatosuccinimide has been accomplished by Lewis acid catalysis with CuOTf under mild conditions. It was suggested that the electrophilic thiocyanating reagent was activated by CuOTf, and difunctionalization was achieved through a thiocyanation/spirocyclization pathway. Thus, a series of thiocyanato-containing spiroketals were obtained in moderate to high yields. It provides an alternative approach for the synthesis of functionalized [6,5]/[5,5]-spiroketals.
源语言 | 英语 |
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页(从-至) | 4216-4219 |
页数 | 4 |
期刊 | Organic and Biomolecular Chemistry |
卷 | 21 |
期 | 20 |
DOI | |
出版状态 | 已出版 - 3 5月 2023 |