Copper-Catalyzed Remote C5-Selective Chlorination of 8-Amidoquinolines Using Sulfonyl Chlorides as Cl Source

Han Zhang; Miao Xu; Ningning Liu; Fanzhi Yang

doi:10.1002/slct.202100030

Copper-Catalyzed Remote C5-Selective Chlorination of 8-Amidoquinolines Using Sulfonyl Chlorides as Cl Source

Han Zhang, Miao Xu, Ningning Liu, Fanzhi Yang^*

^*此作品的通讯作者

前沿交叉科学研究院

Beijing Institute of Technology

科研成果: 期刊稿件 › 文章 › 同行评审

4 引用（Scopus）

摘要

Sulfonyl chloride has been rarely used as Cl source in transition metal-catalyzed C−H functionalizations. We report the unprecedented copper-catalyzed remote C5-chlorination of substituted 8-amidoquinolines with sulfonyl chloride under 1 atm oxygen. 10 sulfonyl chlorides and 15 substituted 8-amidoquinolines were tested, generating moderate to high yields. The catalytic system showed high regio-selectivity, as well as good functional group tolerance.

源语言	英语
页（从-至）	2319-2322
页数	4
期刊	ChemistrySelect
卷	6
期	9
DOI	https://doi.org/10.1002/slct.202100030
出版状态	已出版 - 5 3月 2021

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Zhang, H., Xu, M., Liu, N., & Yang, F. (2021). Copper-Catalyzed Remote C5-Selective Chlorination of 8-Amidoquinolines Using Sulfonyl Chlorides as Cl Source. ChemistrySelect, 6(9), 2319-2322. https://doi.org/10.1002/slct.202100030

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abstract = "Sulfonyl chloride has been rarely used as Cl source in transition metal-catalyzed C−H functionalizations. We report the unprecedented copper-catalyzed remote C5-chlorination of substituted 8-amidoquinolines with sulfonyl chloride under 1 atm oxygen. 10 sulfonyl chlorides and 15 substituted 8-amidoquinolines were tested, generating moderate to high yields. The catalytic system showed high regio-selectivity, as well as good functional group tolerance.",

keywords = "chlorination, copper catalysis, quinoline, remote selectivity, sulfonyl chloride",

author = "Han Zhang and Miao Xu and Ningning Liu and Fanzhi Yang",

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doi = "10.1002/slct.202100030",

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AU - Zhang, Han

AU - Xu, Miao

AU - Liu, Ningning

AU - Yang, Fanzhi

PY - 2021/3/5

Y1 - 2021/3/5

N2 - Sulfonyl chloride has been rarely used as Cl source in transition metal-catalyzed C−H functionalizations. We report the unprecedented copper-catalyzed remote C5-chlorination of substituted 8-amidoquinolines with sulfonyl chloride under 1 atm oxygen. 10 sulfonyl chlorides and 15 substituted 8-amidoquinolines were tested, generating moderate to high yields. The catalytic system showed high regio-selectivity, as well as good functional group tolerance.

AB - Sulfonyl chloride has been rarely used as Cl source in transition metal-catalyzed C−H functionalizations. We report the unprecedented copper-catalyzed remote C5-chlorination of substituted 8-amidoquinolines with sulfonyl chloride under 1 atm oxygen. 10 sulfonyl chlorides and 15 substituted 8-amidoquinolines were tested, generating moderate to high yields. The catalytic system showed high regio-selectivity, as well as good functional group tolerance.

KW - chlorination

KW - copper catalysis

KW - quinoline

KW - remote selectivity

KW - sulfonyl chloride

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JO - ChemistrySelect

JF - ChemistrySelect

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ER -

Copper-Catalyzed Remote C5-Selective Chlorination of 8-Amidoquinolines Using Sulfonyl Chlorides as Cl Source

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