TY - JOUR
T1 - Controlled Recognition and Corona Formation by Cascade Micellar Nanoprobes
T2 - For Boosting Glioma Theranostics
AU - Yu, Yao
AU - Wang, Minxuan
AU - Li, Mengzhen
AU - Zhang, Limin
AU - Zhao, Jinge
AU - Cao, Jie
AU - Wang, Weizhi
N1 - Publisher Copyright:
© 2022 American Chemical Society. All rights reserved.
PY - 2022/8/16
Y1 - 2022/8/16
N2 - Both tumor-cell-targeting and BBB (blood-brain barrier)-penetrating ability are the key characteristics for glioma theranostics. We established one type of nanomicellar probe functionalized with a newly developed peptide WES. The micellar system could enact a series of cascaded functions in living bodies. It could specifically recruit the ApoE corona in blood circulation rather than perform nonspecific protein absorption. Following, it could penetrate into the BBB in an active manner. Finally, and most importantly, it could recognize and target the tumor marker as well as deliver drugs effectively toward glioma. The cascaded micellar system has shown satisfactory therapeutic ability for glioma in both a subcutaneous and orthotopic model, which provides a prospective strategy for brain cancer treatment.
AB - Both tumor-cell-targeting and BBB (blood-brain barrier)-penetrating ability are the key characteristics for glioma theranostics. We established one type of nanomicellar probe functionalized with a newly developed peptide WES. The micellar system could enact a series of cascaded functions in living bodies. It could specifically recruit the ApoE corona in blood circulation rather than perform nonspecific protein absorption. Following, it could penetrate into the BBB in an active manner. Finally, and most importantly, it could recognize and target the tumor marker as well as deliver drugs effectively toward glioma. The cascaded micellar system has shown satisfactory therapeutic ability for glioma in both a subcutaneous and orthotopic model, which provides a prospective strategy for brain cancer treatment.
UR - http://www.scopus.com/inward/record.url?scp=85135901089&partnerID=8YFLogxK
U2 - 10.1021/acs.analchem.2c02501
DO - 10.1021/acs.analchem.2c02501
M3 - Article
AN - SCOPUS:85135901089
SN - 0003-2700
VL - 94
SP - 11118
EP - 11123
JO - Analytical Chemistry
JF - Analytical Chemistry
IS - 32
ER -
