Cochlear implant/MXene-based electroacoustic stimulation modulates the growth and maturation of spiral ganglion neurons

Yangnan Hu, Hao Wei, Menghui Liao, Shanying Han, Xin Gao, Yusong Wang, Shan Zhou, Dongyu Xu, Xugang Zhuang, Ye Yang, Hong Cheng, Bin Zhang, Qingyue Cui, Jieyu Qi, Lei Tian*, Wenyan Li, Xia Gao, Renjie Chai

*此作品的通讯作者

科研成果: 期刊稿件文章同行评审

摘要

Cochlear implantation (CI) offers a dependable treatment for sensorineural hearing loss, with precision electroacoustic stimulation parameters showing great potential in improving auditory outcomes in CI patients. Here, we report the attachment of MXene into CI systems which effectively mimic the neural electrode interface due to MXene's excellent electrical conductivity and biocompatibility. Low-frequency short-term biphasic electrical pulses emitted by the MXenes-based CI promoted the outgrowth of spiral ganglion neuron (SGN) neurites and growth cones, substantially boosting the calcium activity in SGNs. This study lays a theoretical foundation for the precision medicine approaches in CI patient care, and informs the selection of materials for cochlear implant electrode materials in the future.

源语言英语
页(从-至)443-451
页数9
期刊Engineered Regeneration
5
4
DOI
出版状态已出版 - 12月 2024

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