TY - JOUR
T1 - Chiral hydrogen-bonded organic frameworks used as a chiral stationary phase for chiral separation in gas chromatography
AU - Wang, Wei
AU - Zhang, Yukui
AU - Tang, Bo
AU - Hou, Huipeng
AU - Tang, Shanshan
AU - Luo, Aiqin
N1 - Publisher Copyright:
© 2022 Elsevier B.V.
PY - 2022/7/19
Y1 - 2022/7/19
N2 - Hydrogen-bonded organic frameworks (HOFs) are two dimensional (2D) or three dimensional (3D) porous crystalline materials constructed by Hydrogen bond interaction. In recent years, a variety of functional HOF materials have been successfully synthesized and used in structural identification, environmental pollutant removal, chiral resolution, drug delivery, fluorescence sensing, etc. Here, we first reported that a HOF to coated capillary column for high-resolution gas chromatographic separation of a wide range of analytes, including n-alkanes, n-alcohols, polycyclic aromatic hydrocarbons, and positional isomers, especially for racemates, the HOFs column showed excellent separation repeatability and reproducibility. The relative standard deviation (RSD) values for the retention times were in the range of 0.37–2.43% for run to run (n = 3), 0.38–2.51% for day-to-day (n = 3), and 0.31–2.54% for column-to-column (n = 3), respectively. Moreover, we applied density-functional theory to calculate the adsorption of enantiomers in HOF structures. This work proved that the HOFs had great application prospects as stationary phase in gas chromatography.
AB - Hydrogen-bonded organic frameworks (HOFs) are two dimensional (2D) or three dimensional (3D) porous crystalline materials constructed by Hydrogen bond interaction. In recent years, a variety of functional HOF materials have been successfully synthesized and used in structural identification, environmental pollutant removal, chiral resolution, drug delivery, fluorescence sensing, etc. Here, we first reported that a HOF to coated capillary column for high-resolution gas chromatographic separation of a wide range of analytes, including n-alkanes, n-alcohols, polycyclic aromatic hydrocarbons, and positional isomers, especially for racemates, the HOFs column showed excellent separation repeatability and reproducibility. The relative standard deviation (RSD) values for the retention times were in the range of 0.37–2.43% for run to run (n = 3), 0.38–2.51% for day-to-day (n = 3), and 0.31–2.54% for column-to-column (n = 3), respectively. Moreover, we applied density-functional theory to calculate the adsorption of enantiomers in HOF structures. This work proved that the HOFs had great application prospects as stationary phase in gas chromatography.
KW - Capillary column
KW - Chiral separation
KW - Chiral stationary phase
KW - Hydrogen-bonded organic frameworks
UR - http://www.scopus.com/inward/record.url?scp=85131460783&partnerID=8YFLogxK
U2 - 10.1016/j.chroma.2022.463150
DO - 10.1016/j.chroma.2022.463150
M3 - Article
C2 - 35660319
AN - SCOPUS:85131460783
SN - 0021-9673
VL - 1675
JO - Journal of Chromatography A
JF - Journal of Chromatography A
M1 - 463150
ER -