Chemical Communication and Protocell-Matrix Dynamics in Segregated Colloidosome Micro-Colonies

Hannah Taylor, Ning Gao, Stephen Mann*

*此作品的通讯作者

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9 引用 (Scopus)

摘要

Despite an emerging catalogue of collective behaviours in communities of homogeneously distributed cell-like objects, microscale protocell colonies with spatially segregated populations have received minimal attention. Here, we use microfluidics to fabricate Janus-like calcium alginate hydrogel microspheres with spatially partitioned populations of enzyme-containing inorganic colloidosomes and investigate their potential as integrated platforms for domain-mediated chemical communication and programmable protocell-matrix dynamics. Diffusive chemical signalling within the segregated communities gives rise to increased initial enzyme kinetics compared with a homogeneous distribution of protocells. We employ competing enzyme-mediated hydrogel crosslinking and decrosslinking reactions in different domains of the partitioned colonies to undertake selective expulsion of a specific protocell population from the community. Our results offer new possibilities for the design and construction of spatially organized cytomimetic consortia capable of endogenous chemical processing and protocell-environment interactivity.

源语言英语
文章编号e202300932
期刊Angewandte Chemie - International Edition
62
24
DOI
出版状态已出版 - 12 6月 2023
已对外发布

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