Catalytic asymmetric construction of spiro(γ-butyrolactam-γ- butyrolactone) moieties through sequential reactions of cyclic imino esters with Morita-Baylis-Hillman bromides

Huai Long Teng, He Huang, Chun Jiang Wang*

*此作品的通讯作者

科研成果: 期刊稿件文章同行评审

44 引用 (Scopus)

摘要

Spiro(γ-butyrolactam-γ-butyrolactone): A route to enantioenriched spiro(γ-butyrolactam-γ-butyrolactone) compounds, a valuable motif for drug discovery, was developed by use of a highly efficient copper(I)/TF-BiphamPhos-catalyzed tandem Michael addition-elimination of homoserine lactone derived cyclic imino esters with Morita-Baylis-Hillman (MBH) bromides, followed by treatment with para-toluenesulfonic acid (see scheme).

源语言英语
页(从-至)12614-12618
页数5
期刊Chemistry - A European Journal
18
40
DOI
出版状态已出版 - 1 10月 2012
已对外发布

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