BIODYNAMICAL IMPLICATIONS OF GRAFTING POSITION ALTERATION IN ENGINEERED MIMICS OF PARKINSON'S INHIBITOR MCoCP4

Nevena Ilieva*, Elena Lilkova, Peicho Petkov, Xubiao Peng, Yadi Cheng

*此作品的通讯作者

科研成果: 期刊稿件文章同行评审

摘要

Proteins are currently the fastest-growing class of new therapeutic compounds but smaller proteins and peptides are generally not suitable for use as drugs. Using cyclotides - special knotted proteins stabilized by three pairs of disulphide bonds - as a transport means by grafting onto them as a scaffolding the bioactive peptides can enhance their stability, cellular uptake, and overall efficacy. Experimental methods for creating peptide aptamers are highly time- and resources-consuming. In silico approaches may speed up this process by pre-selecting the drug candidates based on certain biodynamic criteria. In this study, we probe the hypothesis about a relation between the scaffolding conformational stability in conjunction with certain plasticity upon grafting of functionally important domains and the desired biological activity of the modified through the grafting process molecules.

源语言英语
页(从-至)213-220
页数8
期刊Comptes Rendus de L'Academie Bulgare des Sciences
77
2
DOI
出版状态已出版 - 2024

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引用此

Ilieva, N., Lilkova, E., Petkov, P., Peng, X., & Cheng, Y. (2024). BIODYNAMICAL IMPLICATIONS OF GRAFTING POSITION ALTERATION IN ENGINEERED MIMICS OF PARKINSON'S INHIBITOR MCoCP4. Comptes Rendus de L'Academie Bulgare des Sciences, 77(2), 213-220. https://doi.org/10.7546/CRABS.2024.02.06