Automated synthesis of 18F-fluoroacetate using explora FDG 4 module

Li Quan Sun; Ai Qin Luo; Yasuhisa Fujibayashi

doi:10.1109/ICBBE.2009.5162426

Automated synthesis of ¹⁸F-fluoroacetate using explora FDG ₄ module

Li Quan Sun^*, Ai Qin Luo, Yasuhisa Fujibayashi

^*此作品的通讯作者

生命学院

科研成果: 书/报告/会议事项章节 › 会议稿件 › 同行评审

1 引用（Scopus）

摘要

As radio-labeled acetate is a good candidate to detect glial metabolism in brains and prostate cancer, ethyl and sodium [¹⁸F]fluoroacetates were utilized in clinical PET check. A simple and fast method for preparation of ethyl and sodium [¹⁸F]fluoroacetates using Explora FDG₄ module has been established. By this development, it has become possible to obtain ethyl and sodium [¹⁸F]fluoroacetate in a short synthesis time of 39 and 43 min and with a reproducible radiochemical yield of 49.6 ± 4.7% and 43.1 ± 5.2%, (decay corrected). The radiochemical purity of ethyl and sodium [¹⁸F]fluoroacetates were more than 95%.

源语言	英语
主期刊名	3rd International Conference on Bioinformatics and Biomedical Engineering, iCBBE 2009
DOI	https://doi.org/10.1109/ICBBE.2009.5162426
出版状态	已出版 - 2009
活动	3rd International Conference on Bioinformatics and Biomedical Engineering, iCBBE 2009 - Beijing, 中国期限: 11 6月 2009 → 13 6月 2009

出版系列

姓名	3rd International Conference on Bioinformatics and Biomedical Engineering, iCBBE 2009

会议

会议	3rd International Conference on Bioinformatics and Biomedical Engineering, iCBBE 2009
国家/地区	中国
市	Beijing
时期	11/06/09 → 13/06/09

联合国可持续发展目标

此成果有助于实现下列可持续发展目标：

访问文件

10.1109/ICBBE.2009.5162426

其它文件与链接

链接到 Scopus 的出版物

引用此

@inproceedings{da19211541f645f796341ba376e29510,

title = "Automated synthesis of 18F-fluoroacetate using explora FDG 4 module",

abstract = "As radio-labeled acetate is a good candidate to detect glial metabolism in brains and prostate cancer, ethyl and sodium [18F]fluoroacetates were utilized in clinical PET check. A simple and fast method for preparation of ethyl and sodium [18F]fluoroacetates using Explora FDG4 module has been established. By this development, it has become possible to obtain ethyl and sodium [18F]fluoroacetate in a short synthesis time of 39 and 43 min and with a reproducible radiochemical yield of 49.6 ± 4.7% and 43.1 ± 5.2%, (decay corrected). The radiochemical purity of ethyl and sodium [18F]fluoroacetates were more than 95%.",

keywords = "Automated synthesis, Explora FDG module, PET tracer, [F]fluoroacetates",

author = "Sun, {Li Quan} and Luo, {Ai Qin} and Yasuhisa Fujibayashi",

year = "2009",

doi = "10.1109/ICBBE.2009.5162426",

language = "English",

isbn = "9781424429028",

series = "3rd International Conference on Bioinformatics and Biomedical Engineering, iCBBE 2009",

booktitle = "3rd International Conference on Bioinformatics and Biomedical Engineering, iCBBE 2009",

note = "3rd International Conference on Bioinformatics and Biomedical Engineering, iCBBE 2009 ; Conference date: 11-06-2009 Through 13-06-2009",

}

Sun, LQ, Luo, AQ & Fujibayashi, Y 2009, Automated synthesis of ¹⁸F-fluoroacetate using explora FDG ₄ module. 在 3rd International Conference on Bioinformatics and Biomedical Engineering, iCBBE 2009., 5162426, 3rd International Conference on Bioinformatics and Biomedical Engineering, iCBBE 2009, 3rd International Conference on Bioinformatics and Biomedical Engineering, iCBBE 2009, Beijing, 中国, 11/06/09. https://doi.org/10.1109/ICBBE.2009.5162426

Automated synthesis of ¹⁸F-fluoroacetate using explora FDG ₄ module. / Sun, Li Quan; Luo, Ai Qin; Fujibayashi, Yasuhisa.
3rd International Conference on Bioinformatics and Biomedical Engineering, iCBBE 2009. 2009. 5162426 (3rd International Conference on Bioinformatics and Biomedical Engineering, iCBBE 2009).

科研成果: 书/报告/会议事项章节 › 会议稿件 › 同行评审

TY - GEN

T1 - Automated synthesis of 18F-fluoroacetate using explora FDG 4 module

AU - Sun, Li Quan

AU - Luo, Ai Qin

AU - Fujibayashi, Yasuhisa

PY - 2009

Y1 - 2009

N2 - As radio-labeled acetate is a good candidate to detect glial metabolism in brains and prostate cancer, ethyl and sodium [18F]fluoroacetates were utilized in clinical PET check. A simple and fast method for preparation of ethyl and sodium [18F]fluoroacetates using Explora FDG4 module has been established. By this development, it has become possible to obtain ethyl and sodium [18F]fluoroacetate in a short synthesis time of 39 and 43 min and with a reproducible radiochemical yield of 49.6 ± 4.7% and 43.1 ± 5.2%, (decay corrected). The radiochemical purity of ethyl and sodium [18F]fluoroacetates were more than 95%.

AB - As radio-labeled acetate is a good candidate to detect glial metabolism in brains and prostate cancer, ethyl and sodium [18F]fluoroacetates were utilized in clinical PET check. A simple and fast method for preparation of ethyl and sodium [18F]fluoroacetates using Explora FDG4 module has been established. By this development, it has become possible to obtain ethyl and sodium [18F]fluoroacetate in a short synthesis time of 39 and 43 min and with a reproducible radiochemical yield of 49.6 ± 4.7% and 43.1 ± 5.2%, (decay corrected). The radiochemical purity of ethyl and sodium [18F]fluoroacetates were more than 95%.

KW - Automated synthesis

KW - Explora FDG module

KW - PET tracer

KW - [F]fluoroacetates

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DO - 10.1109/ICBBE.2009.5162426

M3 - Conference contribution

AN - SCOPUS:72749094994

SN - 9781424429028

T3 - 3rd International Conference on Bioinformatics and Biomedical Engineering, iCBBE 2009

BT - 3rd International Conference on Bioinformatics and Biomedical Engineering, iCBBE 2009

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