摘要
2′,4″-O-bis(trimethylsilyl)erythromycin A 9-0-(1- ethoxycyclohexyl)oxime was prepared for the regioselective methylation by using 1-ethoxycyclohexene as etherification agents and 1,1,1,3,3,3- hexamethyldisilazane as silylation reagents. Four successive reactions from erythromycin A oxime to clarithromycin were operated in the form of one-pot protection (including etherification and silylation), regioselective methylation and one-pot deprotection with overall yield 49.5%.
| 源语言 | 英语 |
|---|---|
| 页（从-至） | 438-441 |
| 页数 | 4 |
| 期刊 | Chinese Journal of Organic Chemistry |
| 卷 | 25 |
| 期 | 4 |
| 出版状态 | 已出版 - 4月 2005 |