An Efficient Synthesis of Quinoxalinone Derivatives as Potent Inhibitors of Aldose Reductase

Yanchun Yang, Shuzhen Zhang, Bobin Wu, Mingming Ma, Xin Chen, Xiangyu Qin, Minlan He, Saghir Hussain, Chaojun Jing, Bing Ma, Changjin Zhu*

*此作品的通讯作者

科研成果: 期刊稿件文章同行评审

78 引用 (Scopus)

摘要

A novel and facile synthesis of quinoxalinone derivatives was developed in which a wide range of 3-chloroquinoxalin-2(1H)-ones as key intermediates can be generated chemo- and regioselectively in good yields from corresponding quinoxaline-2,3(1H,4H)-diones. This new protocol is arguably superior, as it allows the design and preparation of a variety of bioactive quinoxaline-based compounds, which are particularly effective in the treatment of diabetes and its complications. Through this procedure, a new class of quinoxalinone-based aldose reductase inhibitors were synthesized successfully. Most of the inhibitors, with an N1-acetic acid head group and a substituted C3-phenoxy side chain, proved to be potent and selective. Their IC 50 values ranged from 11.4 to 74.8nM. Among them, 2-(3-(4-bromophenoxy)-7-fluoro-2-oxoquinoxalin-1(2H)-yl)acetic acid and 2-(6-bromo-3-(4-bromophenoxy)-2-oxoquinoxalin-1(2H)-yl)acetic acid were the most active. Structure-activity relationship and molecular docking studies highlighted the importance of the ether spacer in the C3-phenoxy side chains, and provided clear guidance on the contribution of substitutions both at the core structure and the side chain to activity.

源语言英语
页(从-至)823-835
页数13
期刊ChemMedChem
7
5
DOI
出版状态已出版 - 5月 2012

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