TY - GEN
T1 - Alterations in emotional and salience responses to positive stimuli in major depressive disorder
AU - Yang, Yang
AU - Feng, Lei
AU - Imamura, Kazuyuki
AU - Yang, Xiaojing
AU - Li, Huaizhou
AU - Wang, Gang
AU - Hu, Bin
AU - Lu, Shengfu
AU - Zhong, Ning
N1 - Publisher Copyright:
© Springer International Publishing AG 2016.
PY - 2016
Y1 - 2016
N2 - To find out the influences on the emotionality and attentional deployment caused by depression, we recruited 19 MDD patients and 19 healthy controls, and implemented a task-state fMRI experiment using a distraction task paradigm. Our results showed relatively decreased brain activation in the right precuneus and left DLPFC, in the MDD group compared with the healthy group across the positive, neutral, and negative task conditions. During only the positive condition, decreased subcortical responses and concurrently reduced brain activation in the salience network were found only in MDD patients. Further brain-symptom analysis demonstrated significant correlation between alterations in the key region of the salience network and the depressive severity of the patients. Our findings suggest a crucial role of aberrant salience processes (especially in the anterior insulae) in the abnormal perception of positive stimuli in MDD patients, which is likely to be the underlying pathology of the anhedonia.
AB - To find out the influences on the emotionality and attentional deployment caused by depression, we recruited 19 MDD patients and 19 healthy controls, and implemented a task-state fMRI experiment using a distraction task paradigm. Our results showed relatively decreased brain activation in the right precuneus and left DLPFC, in the MDD group compared with the healthy group across the positive, neutral, and negative task conditions. During only the positive condition, decreased subcortical responses and concurrently reduced brain activation in the salience network were found only in MDD patients. Further brain-symptom analysis demonstrated significant correlation between alterations in the key region of the salience network and the depressive severity of the patients. Our findings suggest a crucial role of aberrant salience processes (especially in the anterior insulae) in the abnormal perception of positive stimuli in MDD patients, which is likely to be the underlying pathology of the anhedonia.
UR - http://www.scopus.com/inward/record.url?scp=84989926181&partnerID=8YFLogxK
U2 - 10.1007/978-3-319-47103-7_12
DO - 10.1007/978-3-319-47103-7_12
M3 - Conference contribution
AN - SCOPUS:84989926181
SN - 9783319471020
T3 - Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
SP - 114
EP - 123
BT - Brain Informatics and Health - International Conference, BIH 2016, Proceedings
A2 - Ali, Hesham
A2 - Shi, Yong
A2 - Ascoli, Giorgio A.
A2 - Khazanchi, Deepak
A2 - Hawrylycz, Michael
PB - Springer Verlag
T2 - International Conference on Brain Informatics and Health, BIH 2016
Y2 - 13 October 2016 through 16 October 2016
ER -