Alkylation of indole and benzofuran with acetals

Ningning Liu; Ling Yang; Bei Yang; Jinbang Wang; Xue Chen; Qinpei Wu

doi:10.6023/cjoc201401038

Alkylation of indole and benzofuran with acetals

Ningning Liu, Ling Yang, Bei Yang, Jinbang Wang, Xue Chen, Qinpei Wu^*

^*此作品的通讯作者

化学与化工学院

Beijing Institute of Technology

科研成果: 期刊稿件 › 文章 › 同行评审

3 引用（Scopus）

摘要

Benzofuran derivatives and bisindolylmethane derivatives are widely present in natural products, and have significant biological activity. Acetals were demonstrated to be efficient alkylating agents in the presence of TMSOTf and 2,4,6-collidine. Bisbenzofuranmethane and bisindolylmethane derivatives were easily obtained via direct alkylation of benzofurnan or indole with a series of acetals including amino, cyclic, acetone, aryl and alkyl acetals. The reaction mechanism was proposed.

源语言	英语
页（从-至）	2523-2528
页数	6
期刊	Chinese Journal of Organic Chemistry
卷	34
期	12
DOI	https://doi.org/10.6023/cjoc201401038
出版状态	已出版 - 1 12月 2014

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title = "Alkylation of indole and benzofuran with acetals",

abstract = "Benzofuran derivatives and bisindolylmethane derivatives are widely present in natural products, and have significant biological activity. Acetals were demonstrated to be efficient alkylating agents in the presence of TMSOTf and 2,4,6-collidine. Bisbenzofuranmethane and bisindolylmethane derivatives were easily obtained via direct alkylation of benzofurnan or indole with a series of acetals including amino, cyclic, acetone, aryl and alkyl acetals. The reaction mechanism was proposed.",

keywords = "Acetal, Alkylation, Benzofuran, Indole",

author = "Ningning Liu and Ling Yang and Bei Yang and Jinbang Wang and Xue Chen and Qinpei Wu",

note = "Publisher Copyright: {\textcopyright} 2014 Chinese Chemical Society & SIOC, CAS",

year = "2014",

month = dec,

day = "1",

doi = "10.6023/cjoc201401038",

language = "English",

volume = "34",

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TY - JOUR

T1 - Alkylation of indole and benzofuran with acetals

AU - Liu, Ningning

AU - Yang, Ling

AU - Yang, Bei

AU - Wang, Jinbang

AU - Chen, Xue

AU - Wu, Qinpei

PY - 2014/12/1

Y1 - 2014/12/1

N2 - Benzofuran derivatives and bisindolylmethane derivatives are widely present in natural products, and have significant biological activity. Acetals were demonstrated to be efficient alkylating agents in the presence of TMSOTf and 2,4,6-collidine. Bisbenzofuranmethane and bisindolylmethane derivatives were easily obtained via direct alkylation of benzofurnan or indole with a series of acetals including amino, cyclic, acetone, aryl and alkyl acetals. The reaction mechanism was proposed.

AB - Benzofuran derivatives and bisindolylmethane derivatives are widely present in natural products, and have significant biological activity. Acetals were demonstrated to be efficient alkylating agents in the presence of TMSOTf and 2,4,6-collidine. Bisbenzofuranmethane and bisindolylmethane derivatives were easily obtained via direct alkylation of benzofurnan or indole with a series of acetals including amino, cyclic, acetone, aryl and alkyl acetals. The reaction mechanism was proposed.

KW - Acetal

KW - Alkylation

KW - Benzofuran

KW - Indole

UR - http://www.scopus.com/inward/record.url?scp=84904864197&partnerID=8YFLogxK

U2 - 10.6023/cjoc201401038

DO - 10.6023/cjoc201401038

M3 - Article

AN - SCOPUS:84904864197

SN - 0253-2786

VL - 34

SP - 2523

EP - 2528

JO - Chinese Journal of Organic Chemistry

JF - Chinese Journal of Organic Chemistry

IS - 12

ER -

Alkylation of indole and benzofuran with acetals

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