@inproceedings{07d69e747d674bffa89259579be0e447,
title = "Alginate-templated microcapsules carrying heparin via layer-by-layer self-assembly",
abstract = "Electrostatic layer-by-layer self-assembly is a simple and effective approach to carry macromolecules into microscale carriers. Calcium-cross-linked alginate hydrogel microspheres were fabricated by an emulsification technique and then used as negatively charged templates for polyelectrolyte multilayer coatings to entrap heparin. The polycation was poly (allylamine hydrochloride) (PAH), while the polyanion was heparin, an anticoagulant to prevent the clotting of blood. The microcapsule was formed via coating {PAH/heparin}3 on Ca2+-cross-linked alginate hydrogel. The retention of alginate in {PAH/heparin}3 microcapsule was confirmed by fluorescence inverted microscopy and confocal laser scanning microscopy. The assembly of polyelectrolyte layers on alginate microspheres was monitored by Zeta Potential Analyzer. The concentration of heparin was detected by HPLC with IR-detector and organic acid column. It was found that heparin could be entrapped in the microcapsules in high efficiency, providing a useful delivery system which would be found potential application in antagonizing thrombosis.",
keywords = "Alginate, Heparin, Layer-by-Layer self-assembly, Microcapsules",
author = "Juan Li and Xinrong Liu and Baoqing Zhu and Yingya Shao and Dongxu Zhao and Xinlin Yang",
year = "2008",
doi = "10.1109/ICBBE.2008.684",
language = "English",
isbn = "9781424417483",
series = "2nd International Conference on Bioinformatics and Biomedical Engineering, iCBBE 2008",
publisher = "IEEE Computer Society",
pages = "1420--1423",
booktitle = "2nd International Conference on Bioinformatics and Biomedical Engineering, iCBBE 2008",
address = "United States",
note = "2nd International Conference on Bioinformatics and Biomedical Engineering, iCBBE 2008 ; Conference date: 16-05-2008 Through 18-05-2008",
}